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Determination of an optimum extraction region for the recovery of bioactive compounds from olive leaves (Olea europaea L.) using green dynamic pressurized liquid extraction

2023Journal article Open access
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dc.contributor.authorSilva, Patricia Sabino da
dc.contributor.authorViell, Franciele Leila Giopato
dc.contributor.authorIneu, Rafael P.
dc.contributor.authorBona, Evandro
dc.contributor.authorDias, Maria Inês
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.contributor.authorGonçalves, Odinei Hess
dc.contributor.authorLeimann, Fernanda Vitória
dc.contributor.authorCardozo-Filho, Lucio
dc.date.accessioned2023-03-08T15:10:49Z
dc.date.available2023-03-08T15:10:49Z
dc.date.issued2023
dc.description.abstractPressurized liquid extraction with water and ethanol was employed to obtain high antioxidant extracts from olive leaves (Olea europaea L.). The influence of solvent ratio (100-50% v/v water/ethanol), temperature (100-200 degrees C), and solvent flow rate (1-5 mL min(-1)) on the extraction process was investigated using a Box-Behnken experimental design. ANOVA was applied to determine the overall goodness of fit of the dependent variables (extraction yield, antioxidant capacity by DPPH, total flavonoids, total iridoid-glycoside, and total phenolic content) in second-order models. For the optimization, these models were used to find the optimal conditions using the Sequential Simplex optimization procedure combined with Derringer and Suich's desirability function to maximize antioxidant capacity, total iridoid-glycoside recovery, and total phenolic content. The optimal region conditions for extraction were determined at a solvent ratio of 53-65% v/v water/ethanol, the extraction temperature of 100-120 degrees C, and a 3-4 mL min(-1) solvent flow rate. Fifteen phenolic compounds were identified in the samples using HPLC-DAD-ESI/MSn, including two phenolic acids (hydroxytyrosol and hydroxytyrosol glucoside), four flavonols (apigenin-6,8-C-dihexoside, quercetin-3-O-rutinoside, luteolin-O-hexoside, and derivatives), and nine iridoid-glycosides (verbascoside, oleuropein, and derivatives). Oleuropein and derivates were identified as the major phenolic compounds in the extract obtained at optimal conditions as a percentage of 89% of the extract composition.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, Patricia Sabino da; Viell, Franciele Leila Giopato; Ineu, Rafael P.; Bona, Evandro; Dias, Maria Inês; Ferreira, Isabel C.F.R.; Barros, Lillian; Goncalves, Odinei Hess; Leimann, Fernanda Vitória; Cardozo-Filho, Lucio (2022). Determination of an optimum extraction region for the recovery of bioactive compounds from olive leaves (Olea europaea L.) using green dynamic pressurized liquid extraction. Brazilian Journal Of Chemical Engineering. EISSN 1678-4383. 40:3, p. 1-19pt_PT
dc.identifier.doi10.1007/s43153-022-00268-w
dc.identifier.eissn1678-4383
dc.identifier.issn0104-6632
dc.identifier.urihttp://hdl.handle.net/10198/27566
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Heidelberg
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectSubcritical extractionpt_PT
dc.subjectDesirability functionpt_PT
dc.subjectSequential simplexpt_PT
dc.subjectOlive leafpt_PT
dc.subjectHydroalcoholic solvent
dc.titleDetermination of an optimum extraction region for the recovery of bioactive compounds from olive leaves (Olea europaea L.) using green dynamic pressurized liquid extractionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleBrazilian Journal Of Chemical Engineeringpt_PT
person.familyNameDias
person.familyNameFerreira
person.familyNameBarros
person.familyNameGonçalves
person.familyNameLeimann
person.givenNameMaria Inês
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.givenNameOdinei Hess
person.givenNameFernanda Vitória
person.identifier144781
person.identifier469085
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person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id9335958400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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