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Evaluation of human tumor cell lines growth inhibition by Leccinum vulpinum Watling and Suillus granulatus (L.) Roussel

2013Conference object Open access
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dc.contributor.authorVieira, Vanessa
dc.contributor.authorReis, Filipa S.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorMartins, Anabela
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2013-09-10T09:29:03Z
dc.date.available2013-09-10T09:29:03Z
dc.date.issued2013
dc.description.abstractMushrooms comprise a vast and not yet totally explored source of powerful new pharmaceutical products. In particular, and most importantly for modern medicine, they represent an unlimited source of compounds which are modulators of tumour cell growth [1]. In the present work, the anti-proliferative properties of two methanolic extracts of wild mushroom species from the Northeast of Portugal (Leccinum vulpinum Watling and SuilIus granulatus (L.) Roussel) were evaluated for the first time, allowing the comparison between these two species. These properties were measured by sulforhodamine 8 (SRB) assay according to the procedure adopted in the NCI's in vitro anticancer drug screening, observing their growth inhibitory activity. MCF-7 (breast carcinoma), NCI-H460 (non-small lung carcinoma), HCT-15 (colon carcinoma) and HeLa (cervical carcinoma) human cells lines were used. The concentration that inhibited growth in 50% is expressed in Gl50. Both species were able to inhibit the proliferation of all the tested cell lines. Nevertheless, the most susceptible cell line was HCT-15: Gl50 values 71.31±5.26 μg/ml for S. Ganulatus and 77.61±2.22 μg/ml for L. vulpinum. Up to 400 μg/ml, the samples did not show toxicity for non-tumor porcine liver primary cells. This study contributes for the valorisation of the mentioned mushroom species due to their anti-proliferative properties against human tumor cell lines.por
dc.description.sponsorshipFCT (Portugal) and COMPETE/QREN/EU for financial support through PTDC/AGR/ALI/11 0062/2009 research project and PEst-OE/AGR/UI0690/2011 CIMO strategic project. R.C.C. also thanks to POPH and FSE for the SFRH/BPD/68344/2010 grant.por
dc.identifier.citationVieira, Vanessa; Reis, Filipa S.; Calhelha, Ricardo C.; Martins, Anabela; Ferreira, Isabel C.F.R. (2013). Evaluation of human tumor cell lines growth inhibition by Leccinum vulpinum Watling and Suillus granulatus (L.) Roussel. In 1st Symposium on Medicinal Chemistry. Bragapor
dc.identifier.urihttp://hdl.handle.net/10198/8703
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.relationStrategic Project - UI 690 - 2011-2012
dc.titleEvaluation of human tumor cell lines growth inhibition by Leccinum vulpinum Watling and Suillus granulatus (L.) Rousselpor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.conferencePlaceBraga, Portugalpor
oaire.citation.title1st Symposium on Medicinal Chemistry of University of Minhopor
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameReis
person.familyNameCalhelha
person.familyNameMartins
person.familyNameFerreira
person.givenNameFilipa S.
person.givenNameRicardo C.
person.givenNameAnabela
person.givenNameIsabel C.F.R.
person.identifier144781
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person.identifier.orcid0000-0002-9159-0530
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-6218-4413
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridI-2093-2013
person.identifier.ridJ-2172-2014
person.identifier.ridG-5488-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36982144400
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id7203013518
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
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