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Phenolic composition, antioxidant, anti-hepattocelular carcinoma and hepatotoxic properties of Cynara scolymus L. (artichoke)

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dc.contributor.authorPereira, Carla
dc.contributor.authorBarros, Lillian
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2015-11-02T11:48:31Z
dc.date.available2015-11-02T11:48:31Z
dc.date.issued2014
dc.description.abstractCynara scolymus L. (artichoke) is a medicinal plant native to the Mediterranean Basin that belongs to the Asteraceae family; it can be eaten (raw, fried, boiled, etc.) or consumed as infusion or dietary supplement (pill, capsule, syrup, etc.). This plant is widely cultivated all over the world being perceived as a nutritious and healthy vegetable due to its antioxidant and hepatoprotective effects [1]. The beneficial properties of medicinal plants can be related to their large diversity of phytochemicals, among which phenolic compounds are outstanding. Thereby, the aim of the present work was to obtain and compare the phenolic profiles of artichoke infusion and hydromethanolic extracts, using HPLCDAD- ESI/MS. Furthermore, the infusion was studied for antioxidant properties (radical scavenging activity, reducing power, and lipid peroxidation inhibition), anti-hepatocellular carcinoma activity (HepG2 tumor cell line) and hepatotoxicity (non-tumor liver cells primary culture). The infusion of artichoke presented higher phenolic compounds concentration (15.29 mg/g) than the hydroalcoholic extract (4.37 mg/g) with slight differences between the respective profiles; luteolin-7-0-glucuronide was the major flavonoid found in infusion and hydroalcoholic extract (5.74 and 0.70 mg/g. respectively), followed by luteolin-7-0- glucoside (2.88 and 0.49 mg/g, respectively). Monocaffeoylquinic derivatives were only present in the hydroalcoholic extract, being 5-0-caffeoylquinic acid (0.49 mg/g) the most abundant one, while dicaffeoylquinic acid derivatives were mostly identified in the infusion; 1 ,3-0-dicaffeoylquinic acid was the most abundant one in both extracts (0.90 and 0.37 mg/g in the infusion and hydroalcoholic extract, respectively). Regarding the antioxidant activity, the infusion revealed ECso values ranging from 0.14 to 2.13 mg/ml in lipid peroxidation inhibition and radical scavenging activity, respectively. lt also revealed anti-hepatocellular carcinoma activity at 52.06 j..Jg/ml, while presented toxicity in normal cells in concentrations higher than 71.73 j..Jg/ml [2]. All in all, the infusion of artichoke proved to be more effective than the hydroalcoholic extract, revealing interesting effects against oxidative stress and liver damages.pt_PT
dc.identifier.citationPereira, Carla; Barros, Lillian; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2014). Phenolic composition, antioxidant, anti-hepattocelular carcinoma and hepatotoxic properties of Cynara scolymus L. (artichoke). In 8th ISANH World Congress on Polyphenols Applications. Lisbonpt_PT
dc.identifier.urihttp://hdl.handle.net/10198/12236
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationPEst-OE/AGR/U10690/2011
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titlePhenolic composition, antioxidant, anti-hepattocelular carcinoma and hepatotoxic properties of Cynara scolymus L. (artichoke)pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.title8th ISANH world congress on Polyphenols applicationspt_PT
person.familyNamePereira
person.familyNameBarros
person.familyNameFerreira
person.givenNameCarla
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier1415151
person.identifier469085
person.identifier144781
person.identifier.ciencia-idEF10-2739-2B70
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-0093-771X
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridK-1629-2016
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id55627876424
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicatione07a8e12-52bb-47c5-bae7-41a5f648213b
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8

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