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Chemical characterization and bioactivity of phytochemicals from Iberian endemic Santolina semidentata and strategies for ex situ propagation

2015Journal article Open access
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dc.contributor.authorGomes, Andreia Karla
dc.contributor.authorPimpão, Rui
dc.contributor.authorFortalezas, Sofia
dc.contributor.authorFigueira, Inês
dc.contributor.authorMiguel, Célia
dc.contributor.authorAguiar, Carlos
dc.contributor.authorSalgueiro, Lígia
dc.contributor.authorCavaleiro, Carlos
dc.contributor.authorGonçalves, Maria José
dc.contributor.authorClemente, Adelaide
dc.contributor.authorCosta, Catarina
dc.contributor.authorMartins-Loução, Maria Amélia
dc.contributor.authorFerreira, Ricardo B.
dc.contributor.authorSantos, Cláudia N.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2018-03-01T16:04:46Z
dc.date.accessioned2018-03-05T09:19:04Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2018-03-01T16:04:46Z
dc.date.available2018-03-05T09:19:04Z
dc.date.issued2015
dc.description.abstractAsteraceae family members are well-known for their medicinal potential, comprising several properties that make them unique among plants. Here we focus on Santolina semidentata, an endemic plant from the Iberian Peninsula, not yet described for its medicinal properties. Phytochemical characterization of S. semidentata was performed, concerning total phenol content, flavonoid content, antioxidant capacity, HPLC-DAD profile, acetylcholinesterase inhibitory capacity, cytotoxicity and neuroprotective effect in a human neurodegeneration cell model. Moreover, essential oil composition and antifungal activity were also analised. This oil might be useful for therapeutical purposes, particularly in the treatment of dermatophytosis. S. semidentata potential for neuroprotection was revealed by acetylcholinesterase inhibitory capacity and also by an effective protective effect in human neuronal cells. Furthermore, different seed conservation protocols, as well as successful in vitro propagation were established which may be useful when integrated in a broad strategy for the conservation of these endemic plants and their sustainable use for potential biotechnological applications. The results presented here greatly contribute to value this species regarding its potential as a source of phytochemicals with prospective neuroprotective health benefits, either as alternative neuroprotective drugs or as leads for synthetizing more effective molecules.en_EN
dc.description.sponsorshipThe authors wish to thank to “Fundo EDP para a Biodiversidade” for financial support. This work was also supported by “Fundação para a Ciência e a Tecnologia” through grant PEst-OE/EQB/LA0004/2011, BGCT/33418/2008, Green-it: UID/Multi/04551/2013, iNOVA4Health: UID/Multi/04462/2013 and financial support to CNS (IF/01097/20132), RP (SFRH/BD/63615/2009), IF (SFRH/BD/86584/2012) and AG (SFRH/BD/103155/2014).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationGomes, Andreia; Pimpão, Rui C.; Fortalezas, Sofia; Figueira, Inês; Miguel, Célia; Aguiar, Carlos; Salgueiro, Lígia; Cavaleiro, Carlos; Gonçalves, Maria José; Clemente, Adelaide; Costa, Catarina; Martins-Loução, Maria Amélia; Ferreira, Ricardo B.; Santos, Cláudia N. (2015). Chemical characterization and bioactivity of phytochemicals from Iberian endemic Santolina semidentata and strategies for ex situ propagation. Industrial Crops and Products. ISSN 0926-6690. 74, p. 505-513en_EN
dc.identifier.doi10.1016/j.indcrop.2015.04.037en_EN
dc.identifier.isbn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/16103
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationStrategic Project - LA 4 - 2011-2012
dc.relationACTIVIDADES DE GESTÃO EM CIÊNCIA E TECNOLOGIA NO BANCO DE SEMENTES DO JARDIM BOTÂNICO MNHN
dc.relationNEUROPROTECTIVE EFFECTS ON A NEURODEGENERATION CELL MODEL EXHIBITED BY SERUM BIOAVAILABLE METABOLITES OBTAINED FROM A HUMAN INTERVENTION STUDY WITH HIGHLY ANTIOXIDANT FRUITS
dc.relationDECIPHERING THE POTENTIAL OF BLACKBERRY POLYPHENOLS FOR PARKINSON DISEASE: DIGESTION, BLOOD BRAIN BARRIER TRANSPOSITION AND NEUROPROTECTIVE EFFECT
dc.relationDisclosing the mechanisms underlying the beneficial effects of Berries-driven Polyphenols in in vitro, as well as, in vivo Cardiovascular models
dc.subjectAcetylcholinesterase inhibitoren_EN
dc.subjectEssential oilen_EN
dc.subjectIberian endemismen_EN
dc.subjectNeuroprotectionen_EN
dc.subjectPhytomoleculesen_EN
dc.subjectPolyphenolen_EN
dc.subjectPropagation protocolen_EN
dc.subjectSantolina semidentataen_EN
dc.titleChemical characterization and bioactivity of phytochemicals from Iberian endemic Santolina semidentata and strategies for ex situ propagationen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 4 - 2011-2012
oaire.awardTitleACTIVIDADES DE GESTÃO EM CIÊNCIA E TECNOLOGIA NO BANCO DE SEMENTES DO JARDIM BOTÂNICO MNHN
oaire.awardTitleNEUROPROTECTIVE EFFECTS ON A NEURODEGENERATION CELL MODEL EXHIBITED BY SERUM BIOAVAILABLE METABOLITES OBTAINED FROM A HUMAN INTERVENTION STUDY WITH HIGHLY ANTIOXIDANT FRUITS
oaire.awardTitleDECIPHERING THE POTENTIAL OF BLACKBERRY POLYPHENOLS FOR PARKINSON DISEASE: DIGESTION, BLOOD BRAIN BARRIER TRANSPOSITION AND NEUROPROTECTIVE EFFECT
oaire.awardTitleDisclosing the mechanisms underlying the beneficial effects of Berries-driven Polyphenols in in vitro, as well as, in vivo Cardiovascular models
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0004%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBGCT%2F33418%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04551%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04462%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F63615%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F86584%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F103155%2F2014/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStreamOE
person.familyNameAguiar
person.givenNameCarlos
person.identifier.ciencia-id5912-C8F4-7686
person.identifier.orcid0000-0001-8643-7112
person.identifier.ridI-3933-2014
person.identifier.scopus-author-id54413830100
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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