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Effects of a Myrciaria jaboticaba peel extract on starch and triglyceride absorption and the role of cyanidin-3- O -glucoside

2021Journal article Open access
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dc.contributor.authorCastilho, Pâmela Alves
dc.contributor.authorBracht, Lívia
dc.contributor.authorBarros, Lillian
dc.contributor.authorAlbuquerque, Bianca R.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorComar, Jurandir Fernando
dc.contributor.authorSilva, Tamires Barlati Vieira
dc.contributor.authorPeralta, Rosane M.
dc.contributor.authorSá-Nakanishi, Anacharis B. de
dc.contributor.authorBracht, Adelar
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-23T12:12:52Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-23T12:12:52Z
dc.date.issued2021
dc.description.abstractThe purpose of this study was to perform a parallel and comparative investigation of the effects of a Myrciaria jaboticaba (common name jabuticaba) peel extract and of its constituent cyanidin-3-O-glucoside on the overall process of starch and triglyceride intestinal absorption. The peel extract inhibited both the porcine pancreactic α-amylase and the pancreatic lipase but was 13.6 times more potent on the latter (IC50 values of 1963 and 143.9 μg mL-1, respectively). Cyanidin-3-O-glucoside did not contribute significantly to these inhibitions. The jabuticaba peel extract inhibited starch absorption in mice at doses that were compatible with its inhibitory action on the α-amylase. No inhibition of starch absorption was found with cyanidin-3-O-glucoside doses compatible with its content in the extract. The extract also inhibited triglyceride absorption, but at doses that were considerably smaller than those predicted by its strength in inhibiting the pancreatic lipase (ID50 = 3.65 mg kg-1). In this case, cyanidin-3-O-glucoside was also strongly inhibitory, with 72% inhibition at the dose of 2 mg kg-1. When oleate + glycerol were given to mice, both the peel extract and cyanidin-3-O-glucoside strongly inhibited the appearance of triglycerides in the plasma. The main mechanism seems, thus, not to be the lipase inhibition but rather the inhibition of one or more steps (e.g., transport) in the events that lead to the transformation of free fatty acids in the intestinal tract into triglycerides. Due to the low active doses, the jabuticaba peel extract presents many favourable perspectives as an inhibitor of fat absorption and cyanidin-3-O-glucoside seems to play a decisive role. This journal is.en_EN
dc.description.sponsorshipThis work was financially supported by grants from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq-304090/2016-6) and Coordenação do Aperfeiçoamento de Pessoal do Ensino Superior (CAPES). The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020) and through the institutional scientific employment program-contract for L. Barros contract. This work was also funded by the European Regional Development Fund (ERDF) through the Regional Operational Program North 2020, within the scope of Project Mobilizador Norte-01-0247-FEDER-024479: ValorNatural®.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationAlves Castilho, Pamela; Bracht, Lívia; Barros, Lillian; Albuquerque, Bianca R.; Dias, Maria Inês; Ferreira, Isabel C.F.R.; Comar, Jurandir Fernando; Barlati Vieira Da Silva, Tamires; Peralta, Rosane Marina; Sá-Nakanishi, Anacharis Babeto De; Bracht, Adelar (2021). Effects of a Myrciaria jaboticaba peel extract on starch and triglyceride absorption and the role of cyanidin-3- O -glucoside. Food and Function. ISSN 2042-6496. 12:6, p. 2644-2659en_EN
dc.identifier.doi10.1039/d0fo02927ken_EN
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/24378
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.titleEffects of a Myrciaria jaboticaba peel extract on starch and triglyceride absorption and the role of cyanidin-3- O -glucosideen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarros
person.familyNameAlbuquerque
person.familyNameDias
person.familyNameFerreira
person.givenNameLillian
person.givenNameBianca R.
person.givenNameMaria Inês
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id621C-B603-7519
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4109-7921
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridM-8242-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id57192311941
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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