Repository logo
 
Publication

Environmental azole fungicide, prochloraz, can induce cross-resistance to medical triazoles in Candida glabrata

2014Journal article Open access
Simple item page
dc.contributor.authorFaria-Ramos, Isabel
dc.contributor.authorTavares, Pedro Ribeiro
dc.contributor.authorFarinha, Sofia
dc.contributor.authorNeves-Maia, João
dc.contributor.authorMiranda, Isabel M.
dc.contributor.authorSilva, Raquel M.
dc.contributor.authorEstevinho, Leticia M.
dc.contributor.authorPina-Vaz, Cidália
dc.contributor.authorRodrigues, Acácio G.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2018-03-08T15:14:41Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2018-03-08T15:14:41Z
dc.date.issued2014
dc.description.abstractAcquisition of azole resistance by clinically relevant yeasts in nature may result in a significant, yet undetermined, impact in human health. The main goal of this study was to assess the development of cross-resistance between agricultural and clinical azoles by Candida spp. An in vitro induction assay was performed, for a period of 90 days, with prochloraz (PCZ) - an agricultural antifungal. Afterward, the induced molecular resistance mechanisms were unveiled. MIC value of PCZ increased significantly in all Candida spp. isolates. However, only C. glabrata developed cross-resistance to fluconazole and posaconazole. The increased MIC values were stable. Candida glabrata azole resistance acquisition triggered by PCZ exposure involved the upregulation of the ATP binding cassette multidrug transporter genes and the transcription factor, PDR1. Single mutation previously implicated in azole resistance was found in PDR1 while ERG11 showed several synonymous single nucleotide polymorphisms. These results might explain why C. glabrata is so commonly less susceptible to clinical azoles, suggesting that its exposure to agricultural azole antifungals may be associated to the emergence of cross-resistance. Such studies forward potential explanations for the worldwide increasing clinical prevalence of C. glabrata and the associated worse prognosis of an infection by this species.en_EN
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationFaria-Ramos, Isabel; Tavares, Pedro R.; Farinha, Sofia; Neves-Maia, João; Miranda, Isabel M.; Silva, Raquel M.; Estevinho, Letícia M.; Pina-Vaz, Cidalia; Rodrigues, Acácio G. (2014). Environmental azole fungicide, prochloraz, can induce cross-resistance to medical triazoles in Candida glabrata. FEMS Yeast Research. ISSN 1567-1356. 14:7,p. 1119-1123en_EN
dc.identifier.doi10.1111/1567-1364.12193en_EN
dc.identifier.issn1567-1356
dc.identifier.urihttp://hdl.handle.net/10198/16210
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectAgricultureen_EN
dc.subjectCandida glabrataen_EN
dc.subjectClinical resistanceen_EN
dc.titleEnvironmental azole fungicide, prochloraz, can induce cross-resistance to medical triazoles in Candida glabrataen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameEstevinho
person.givenNameLetícia M.
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id6506577664
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication4a1d5ba2-1854-4ca5-89a4-73f35e964df9
relation.isAuthorOfPublication.latestForDiscovery4a1d5ba2-1854-4ca5-89a4-73f35e964df9

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
298.pdf
Size:
121.94 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Plain Text
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus