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2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species

2007Journal article Open access
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dc.contributor.authorGomes, Ana Sara
dc.contributor.authorFernandes, Eduarda
dc.contributor.authorSilva, Artur
dc.contributor.authorPinto, Diana
dc.contributor.authorSantos, Clementina M.M.
dc.contributor.authorCavaleiro, José
dc.contributor.authorLima, José Costa
dc.date.accessioned2011-04-04T13:46:08Z
dc.date.available2011-04-04T13:46:08Z
dc.date.issued2007
dc.descriptionhttp://apps.isiknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=S2NjaL1GBbk143plPl1&page=1&doc=1&colname=WOSpor
dc.description.abstract2-Styrylchromones are a small group of naturally occurring chromones, vinylogues of flavones (2-phenylchromones). Natural and synthetic 2-styrylchromones have been tested in different biological systems, showing activities with potential therapeutic applications. In particular, the potential and hitherto understudied antioxidant behavior of these compounds has been raised as a matter of interest. Thus the present work consisted in the study of the in vitro scavenging activities for reactive oxygen species (ROS) and reactive nitrogen species (RNS) of various 2-styrylchromone derivatives and structurally similar flavonoids. Some of the studied 2-styrylchromones proved to be extremely efficient scavengers of the different ROS and RNS, showing, in some cases, IC50s under 1 lM. The hydroxylation pattern of 2-styrylchromones, especially in the B-ring but also in the A ring, modulates the activity of these compounds, the catecholic derivatives being the most effective scavengers. The styryl pattern also contributes to their observed outstanding antioxidant activity. In conclusion, the scavenging activities for ROS/RNS of 2-styrylchromone derivatives, here shown for the first time, provide novel and most promising compounds to be applied as antioxidants.por
dc.identifier.citationGomes, Ana; Fernandes, Eduarda; Silva, Artur; ; Santos, Clementina M.M.; Cavaleiro, José; Costa Lima, José (2007). 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 15:18, p. 6027-6036por
dc.identifier.doi10.1016/j.bmc.2007.06.046
dc.identifier.issn0968-0896
dc.identifier.urihttp://hdl.handle.net/10198/3922
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/journal/09680896por
dc.subject2-Styrylchromonespor
dc.subjectReactive oxygen speciespor
dc.subjectReactive nitrogen speciespor
dc.subjectScavenging activitypor
dc.subjectAntioxidant activitypor
dc.title2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen speciespor
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCI%2FQUI%2F59284%2F2004/PT
oaire.citation.endPage6036por
oaire.citation.startPage6027por
oaire.citation.titleBioorganic and Medicinal Chemistrypor
oaire.fundingStreamPOCI
person.familyNameSantos
person.givenNameClementina M.M.
person.identifier.ciencia-id9018-DB9C-C590
person.identifier.orcid0000-0003-4380-7990
person.identifier.scopus-author-id7201458663
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication64f662b6-775d-4ea0-bfd7-f527af0ac1a0
relation.isAuthorOfPublication.latestForDiscovery64f662b6-775d-4ea0-bfd7-f527af0ac1a0
relation.isProjectOfPublication1a77f25c-e459-4679-93cb-48bc8c6709ac
relation.isProjectOfPublication.latestForDiscovery1a77f25c-e459-4679-93cb-48bc8c6709ac

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