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Flowers of allium cepa l. as nutraceuticals: phenolic composition and anti-obesity and antioxidant effects in caenorhabditis elegans

2023Journal article Open access
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dc.contributor.authorMoliner, Cristina
dc.contributor.authorNúñez, Sonia
dc.contributor.authorCasedas, Guillermo
dc.contributor.authorValero, Marta Sofia
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorLópez, Víctor
dc.contributor.authorGomez-Rincon, Carlota
dc.date.accessioned2018-04-10T09:45:11Z
dc.date.available2018-04-10T09:45:11Z
dc.date.issued2023
dc.description.abstractAllium cepa L., commonly known as onion, is one of the most-consumed vegetables. The benefits of the intake of its bulb are well studied and are related to its high polyphenol content. The flowers of onions are also edible; however, there are no studies about their biological properties. Our aim was to determine the polyphenolic profile and assess the antioxidant and anti-obesity capacity of an ethanolic extract from fresh flowers of A. cepa. The phenolic constituents were identified through LC-DAD-ESI/MSn. For the anti-obesity potential, the inhibitory activity against digestive enzymes was measured. Several in vitro assays were carried out to determine the antioxidant capacity. A Caenorhabditis elegans model was used to evaluate the effect of the extract on stress resistance and fat accumulation. For the first time, kaempferol and isorhamnetin glucosides were identified in the flowers. The extract reduced fat accumulation in the nematode and had a high lipase and alpha- glucosidase inhibitory activity. Regarding the antioxidant activity, the extract increased the survival rate of C. elegans exposed to lethal oxidative stress. Moreover, the activities of superoxide dismutase and catalase were enhanced by the extract. Our results demonstrate, for the first time, the antioxidant and anti-obesity activity of onion flowers and their potential use as functional foods and nutraceuticals.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoliner, Cristina; Nunez, Sonia; Casedas, Guillermo; Valero, Marta Sofia; Dias, Maria Inês; Barros, Lillian; Lopez, Victor; Gomez-Rincon, Carlota (2023). Flowers of allium cepa l. as nutraceuticals: phenolic composition and anti-obesity and antioxidant effects in caenorhabditis elegans. Antioxidants. eISSN 2076-3921. 12:3, p. 1-15pt_PT
dc.identifier.doi10.3390/antiox12030720
dc.identifier.eissn2076-3921
dc.identifier.urihttp://hdl.handle.net/10198/16885
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEdible flowerspt_PT
dc.subjectOnionpt_PT
dc.subjectFlavonoidspt_PT
dc.subjectPolyphenolspt_PT
dc.subjectObesitypt_PT
dc.subjectC. elegans
dc.titleFlowers of allium cepa l. as nutraceuticals: phenolic composition and anti-obesity and antioxidant effects in caenorhabditis eleganspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleAntioxidantspt_PT
person.familyNameDias
person.familyNameBarros
person.givenNameMaria Inês
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7ca8432b-e7f4-4116-a56e-9eba0d4403bd
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery7ca8432b-e7f4-4116-a56e-9eba0d4403bd

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