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Bioactivity screening of pinhão (Araucaria Angustifolia (Bertol.) Kuntze) seed extracts: the inhibition of cholinesterases and α-amylases, and cytotoxic and anti-inflammatory activities

2021Journal article Open access
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dc.contributor.authorOliveira, Anielle
dc.contributor.authorMoreira, Thaysa Fernandes Moya
dc.contributor.authorPepinelli, Ana Luísa
dc.contributor.authorCosta, Luis Gustavo Médice Arabel
dc.contributor.authorLeal, Luana Eloísa
dc.contributor.authorSilva, Tamires Barlati Vieira
dc.contributor.authorGonçalves, Odinei Hess
dc.contributor.authorIneu, Rafael P.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorAbreu, Rui M.V.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBracht, Lívia
dc.contributor.authorLeimann, Fernanda Vitória
dc.date.accessioned2021-11-17T15:50:30Z
dc.date.available2021-11-17T15:50:30Z
dc.date.issued2021
dc.description.abstractThe objective of this work was to determine the potential bioactive properties of extracts from bio-residues of pinhão (Araucaria angustifolia (Bertol.) Kuntze) seeds, namely the α-amylase and cholinesterase inhibition, cytotoxicity, and anti-inflammatory properties. The pinhão extracts evaluated were obtained from cooking water (CW) and as an ethanolic extract from residual pinhão seed shells (PS). Catechin was the major compound found in both extracts. The PS extract presented higher antioxidant levels and the better inhibition of human salivary and porcine pancreatic α-amylases when compared to the CW extract. Also, based on in vivo evaluations, the PS extract did not differ significantly from acarbose when compared to a control group. The most potent inhibitor of cholinesterases was the CW extract. No cytotoxicity toward normal cells was detected, and neither extract showed anti-inflammatory activity. The PS extract presented cytotoxic activity toward non-small-cell lung, cervical, hepatocellular and breast carcinoma cell lines. Overall, the results demonstrated the potential bioactivity of extracts obtained from pinhão bioresidues.pt_PT
dc.description.sponsorshipThe authors thank CNPq (Chamada Universal – MCTI/CNPq No. 28/2018, Process 421541/2018-0) and Fundação Araucária (convênio 039/2019) for financial support. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001. The authors thank Central Analítica Multiusuário da UTFPR Campo Mourão (CAMulti-CM) for analysis. Project POCI-01-0145-FEDER-006984 – Associated Laboratory LSRE-LCM was funded by FEDER funds through COMPETE2020 – Programa Operacional Competitividade e Internacionalização (POCI) and by national funds through FCT – Fundação para a Ciência e a Tecnologia. The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020). M. I. Dias and L. Barros would like to acknowledge national funding from FCT, P. I., through the institutional scientific employment program-contract.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira, Anielle de; Moreira, Thaysa Fernandes Moya; Pepinelli, Ana Luisa Silva; Costa, Luis Gustavo Médice Arabel; Leal, Luana Eloísa; Silva, Tamires Barlati Vieira da; Gonçalves, Odinei Hess; Ineu, Rafael Porto; Dias, Maria Inês; Barros, Lillian; Abreu, Rui M. V.; Ferreira, Isabel C. F. R.; Bracht, Lívia; Leimann, Fernanda Vitória (2021). Bioactivity screening of pinhão (Araucaria Angustifolia (Bertol.) Kuntze) seed extracts: the inhibition of cholinesterases and α-amylases, and cytotoxic and anti-inflammatory activities. Food & Function. ISSN 2042-6496. 12:20, p. 9820-9828pt_PT
dc.identifier.doi10.1039/D1FO01163Dpt_PT
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/24215
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBioactivitypt_PT
dc.subjectCell culturept_PT
dc.subjectCytotoxicitypt_PT
dc.titleBioactivity screening of pinhão (Araucaria Angustifolia (Bertol.) Kuntze) seed extracts: the inhibition of cholinesterases and α-amylases, and cytotoxic and anti-inflammatory activitiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage9828pt_PT
oaire.citation.issue20pt_PT
oaire.citation.startPage9820pt_PT
oaire.citation.titleFood & Functionpt_PT
oaire.citation.volume12pt_PT
person.familyNameGonçalves
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person.familyNameLeimann
person.givenNameOdinei Hess
person.givenNameMaria Inês
person.givenNameLillian
person.givenNameRui M.V.
person.givenNameIsabel C.F.R.
person.givenNameFernanda Vitória
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rcaap.typearticlept_PT
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