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Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.

2018Journal article Open access
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dc.contributor.authorVieira, Vanessa
dc.contributor.authorPrieto Lage, Miguel A.
dc.contributor.authorBarros, Lillian
dc.contributor.authorCoutinho, João A.P.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorFerreira, Olga
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2018-07-31T15:23:02Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2018-07-31T15:23:02Z
dc.date.issued2018
dc.description.abstractThe extraction of phenolic compounds from walnut leaves (Juglans regia L.) was optimized using heat-assisted extraction and deep eutectic solvents based on choline chloride and carboxylic acids. A preliminary solvent screening was performed using a selected group of carboxylic acids as hydrogen bond donors, showing that the highest extraction yield of phenolic compounds was obtained using choline chloride mixtures with butyric or phenylpropionic acid at a mole ratio 1:2, with 20% of water (w/w). The extraction conditions (time, temperature and water proportion) were then optimized by an experimental design, assisted by response surface methodology. To evaluate the response, the three most abundant compounds identified by HPLC (neochlorogenic acid, quercetin 3-O-glucoside and quercetin O-pentoside) were quantified. Additionally, the solid/liquid ratio effect at the optimal conditions, in dose-response format, was studied in view of its upscale, not showing any significant decrease until 140 g/L. The results here presented provide valuable information towards the design of a process in a pre-industrial form for the extraction of phenolic compounds from J. regia leaves using deep eutectic solvents.
dc.description.sponsorshipThe authors thank the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013), V. Vieira (SFRH/BD/108487/2015) grant and L. Barros contract. To project POCI-01-0145-FEDER-006984 – Associate Laboratory LSRE-LCM funded by FEDER through COMPETE2020 – Programa Operacional Competitividade e Internacionalização (POCI) – and by national funds through FCT – Fundação para a Ciência e a Tecnologia. To project CICECO‐Aveiro Institute of Materials POCI‐01‐0145‐FEDER‐007679 (FCT Ref. UID/ CTM/50011/2013), financed by national funds through the FCT/MEC and when appropriate co‐financed by FEDER under the PT2020 Partnership Agreement. This work is funded by the European Structural and Investment Funds (FEEI) through POCI, within the scope of Project POCI nº 030463. To Xunta de Galicia for financial support for the postdoctoral researcher of M.A. Prieto.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationVieira, Vanessa; Prieto, Miguel A.; Barros, Lillian; Coutinho, João A.P.; Ferreira, Isabel C.F.R.; Ferreira, Olga (2018). Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.. Industrial Crops and Products. ISSN 0926-6690. 115, p. 261-271en_EN
dc.identifier.doi10.1016/j.indcrop.2018.02.029en_EN
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/17075
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationUsing natural deep eutectic solvents for the extraction of bioactive compounds from plant material: valorizing walnut residues through the development of bio-based semi-solid formulas for topical use
dc.subjectDeep eutectic solventsen_EN
dc.subjectHeat-assisted extractionen_EN
dc.subjectJuglans regia L.en_EN
dc.subjectPhenolic compoundsen_EN
dc.subjectResponse surface methodologyen_EN
dc.titleEnhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.en_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleUsing natural deep eutectic solvents for the extraction of bioactive compounds from plant material: valorizing walnut residues through the development of bio-based semi-solid formulas for topical use
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F108487%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FCTM%2F50011%2F2013/PT
oaire.fundingStream5876
person.familyNamePrieto Lage
person.familyNameBarros
person.familyNameFerreira
person.familyNameFerreira
person.givenNameMiguel A.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.givenNameOlga
person.identifier107688
person.identifier469085
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person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id9F1D-C75A-4A54
person.identifier.orcid0000-0002-3513-0054
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0001-8414-3479
person.identifier.ridG-4516-2011
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.ridM-4567-2013
person.identifier.scopus-author-id35937495700
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id57203083219
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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