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Plant extract with bioactive potential against SARS-CoV-2

2021Conference object Open access
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dc.contributor.authorMelo, Adma N.F.
dc.contributor.authorAfonso, Tiago B.
dc.contributor.authorCarvalho, Marta
dc.contributor.authorRodrigues, Cláudia
dc.contributor.authorRibeiro, Tânia
dc.contributor.authorCarocho, Márcio
dc.contributor.authorPinto, Miguel M.
dc.contributor.authorTavaria, Freni K.
dc.contributor.authorTeixeira, Paula
dc.contributor.authorSimas, João P.
dc.contributor.authorBarros, Lillian
dc.contributor.authorPintado, Manuela
dc.date.accessioned2022-02-22T10:38:58Z
dc.date.available2022-02-22T10:38:58Z
dc.date.issued2021
dc.description.abstractThe novel disease caused by SARS·CoV-2 has been causing chaos worldwide due to its high mortality, morbidity and contagiousness nature, and therefore forced the scientific world to develop n'ew alternatives to combat and assist the fight against this virus. Plant extracts have bioactive molecules that might provide a starting point for the research on the use of plants as an excellent source ofoew antiviral agents able to inhibit or neutralize COVID-19. Therefore, the objective ofthis study was to obtain an extract !Tom a Plaot cultivated under controlled conditions in Portugal to be used as ao antiviral substance to be applied against COVID-19. MaterialslMethods: The plant extract obtained !Tom plant cultivated under controlled conditions in Portugal was extracted by maceration in a hydroethanolic solution under optimized conditions and submitted to freeze drying. The extracts were evaluated for their phenolic profile by high performance liquid chromatography coupled to a diode array detector and a mass spectrometer detector (HPLCDAD- MS). Antioxidant activity was also measured, and antiviral properties were measured for SARSCoV- 2 in Vero cells. Remlts. HPLC analysis revealed the presence of different phenolic compounds in the extracts with relevance for caftaric acid, cis-chicoric acid and trans-chychoric acid. The extract showed a good antioxidant capacity demonstrated by the high value found for aRAC of3202,82 ± 32,52 Troloxlmg extrac!. Regarding the antiviral activity, the results achieved for the viral titer was 20 PFU/mL, and the antiviral activity for SARS-CoV-2 was 4.02 ± 0.00 Mv and the perceotage ofreduction was > 99.99%. Conclusion: The results showed that the obtained extract demonstrated consistent results of antiviral activity presenting a potential for applications against the SARS-CoV-2. Further studies are required for validation and application of this extract.pt_PT
dc.description.sponsorshipProject was financed by the European Fund for Regional Development (Fundo Europeu de Desenvolvimento Regional (FEDER)) through the Programa Operacional Regional Norte 2020, within the "PlantCovid" project, NORTE-01-02B7-FEDER-054870pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMelo, Adma N.F.; Afonso, Tiago B.; Carvalho, Marta; Rodrigues, Cláudia; Ribeiro, Tânia; Carocho, Márcio; Pinto, Miguel M.; Tavaria, Freni K.; Teixeira, Paula; Simas, J Pedro; Barros, Lillian; Pintado, Maria Manuela (2021). Plant extract with bioactive potential against SARS-CoV-2. In 4th International Congress of Bíochemistry and Microbiology Applied Technologie: book of abstracts. Hammametpt_PT
dc.identifier.urihttp://hdl.handle.net/10198/25100
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAEAE Congresspt_PT
dc.relationNORTE-01-02B7-FEDER-054870pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMicrobiologypt_PT
dc.titlePlant extract with bioactive potential against SARS-CoV-2pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceHammametpt_PT
oaire.citation.endPage103pt_PT
oaire.citation.startPage103pt_PT
oaire.citation.title4th International Congress of Bíochemistry and Microbiology Applied Technologie: book of abstractspt_PT
person.familyNameCarocho
person.familyNameBarros
person.givenNameMárcio
person.givenNameLillian
person.identifierawbWiiMAAAAJ&hl
person.identifier469085
person.identifier.ciencia-id5614-005B-5CF1
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-8978-4547
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id52463229800
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication46b39e1f-2674-4be1-a96a-c2e5792e6979
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery46b39e1f-2674-4be1-a96a-c2e5792e6979

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