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Propolis influence on erythrocyte membrane disorder (hereditary spherocytosis): a first approach

2011Journal article Open access
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dc.contributor.authorMoreira, Leandro
dc.contributor.authorDias, Teresa
dc.contributor.authorRogão, Mónica
dc.contributor.authorDias, L.G.
dc.contributor.authorSilva, José Paulo
dc.contributor.authorEstevinho, Leticia M.
dc.date.accessioned2011-08-30T09:44:22Z
dc.date.available2011-08-30T09:44:22Z
dc.date.issued2011
dc.description.abstractPropolis is a resinous substance collected from plants by bees. Its composition depends on the vegetation, the season, and the source area. It usually contains many chemical compounds such as polyphenols, steroids and amino acids. The hereditary spherocytosis (HS) is a type of anaemia characterized by microcytic and hyperchromic red cells, spherical in shape and without central pallor. Clinically, subjects present from asymptomatic conditions to severe haemolytic anaemia. In this study it was evaluated the effect of two propolis extracts in the osmotic fragility of HS patient red blood cell (RBC) membrane. It was found that propolis decreases the erythrocytes membrane fragility, being the effect of Bornes propolis more pronounced than Fundão propolis’. This effect was related with the higher phenolic content of the former propolis. The results obtained in vitro suggest that the membrane fragility increases under oxidative stress conditions for the patient RBC’s and the protection effect of propolis is due to its antioxidant properties. These results open doors for future investigations in order to elucidate the mechanisms, identify the main compounds involved in this fragility protection of the erythrocyte membrane. This is the first work reporting an evaluation of the propolis effect in a blood disease.por
dc.identifier.citationMoreira, Leandro; Dias, Teresa; Rogão, Mónica; Dias, Luis G.; Silva, José Paulo; Estevinho, Leticia (2011). Propolis influence on erythrocyte membrane disorder (hereditary spherocytosis): a first approach. Food and Chemical Toxicology. ISSN 0278-6915. 49:2, p. 520-526por
dc.identifier.doi10.1016/j.fct.2010.11.042
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/10198/6054
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectErythrocyte membranepor
dc.subjectBee productspor
dc.titlePropolis influence on erythrocyte membrane disorder (hereditary spherocytosis): a first approachpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage526por
oaire.citation.startPage520por
oaire.citation.titleFood and Chemical Toxicologypor
person.familyNameDias
person.familyNameDias
person.familyNameEstevinho
person.givenNameTeresa
person.givenNameLuís G.
person.givenNameLetícia M.
person.identifier142703
person.identifier.ciencia-id2F11-9092-FAAF
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0002-9419-9561
person.identifier.orcid0000-0002-1210-4259
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id56830642600
person.identifier.scopus-author-id23569169900
person.identifier.scopus-author-id6506577664
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication87c9cae0-314d-4622-ba85-4d3ec5726606
relation.isAuthorOfPublicationeac8c166-4056-4ed0-8d8d-7ecb2c4481a5
relation.isAuthorOfPublication4a1d5ba2-1854-4ca5-89a4-73f35e964df9
relation.isAuthorOfPublication.latestForDiscoveryeac8c166-4056-4ed0-8d8d-7ecb2c4481a5

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