Repository logo
 
Publication

Extraction of aloesin from aloe vera rind using alternative green solvents: Process optimization and biological activity assessment

2021Journal article Open access
Simple item page
dc.contributor.authorAñibarro-Ortega, Mikel
dc.contributor.authorPinela, José
dc.contributor.authorĆirić, Ana
dc.contributor.authorLopes, Elsa
dc.contributor.authorMolina, Adriana K.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorSoković, Marina
dc.contributor.authorFerreira, Olga
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-22T14:46:36Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-22T14:46:36Z
dc.date.issued2021
dc.description.abstractAloesin is an aromatic chromone with increasing applications in the cosmetic and health food industries. To optimize its extraction from the Aloe vera leaf rind, the independent variables time (10–210 min), temperature (25–95â—¦C) and organic solvent composition (0–100%, w/w) were combined in a central composite design coupled with response surface methodology. The solvents consisted of binary mixtures of water with ethanol, propylene glycol, or glycerol. The aloesin levels quantified in each extract were used as response for optimization. The theoretical models were fitted to the experimental data, statistically validated, and used to obtain the optimal extraction conditions. Then, a dose–response analysis of the solid/liquid ratio (S/L) was performed under the optimal conditions determined for each alcohol–water system and revealed that a linear improvement in extraction efficiency can be achieved by increasing the S/L ratio by up to 40 g/L. This analysis also allowed to experimentally validate the predictive models. Furthermore, the aloesin-rich extracts revealed antioxidant activity through thiobarbituric acid reactive substances (TBARS) formation inhibition, antimicrobial effects against bacterial and fungal strains, and no toxicity for PLP2 cells. Overall, this study provided optimal extraction conditions for the recovery of aloesin from Aloe vera rind through an eco-friendly extraction process and highlighted its bioactive potential.en_EN
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020). M. Añibarro-Ortega and A.K. Molina are grateful to FCT, P.I., for their PhD studentships (2020.06297.BD and 2020.06231.BD, respectively), J. Pinela for the contract (CEECIND/01011/2018) through the individual scientific employment program-contract, and L. Barros and R.C. Calhelha through the institutional scientific employment program-contract. To the Project AllNat—POCI-01-0145- FEDER-030463 (PTDC/EQU-EPQ/30463/2017), funded by FEDER funds through COMPETE2020— Programa Operacional Competitividade e Internacionalização (POCI)—and by national funds through FCT/MCTES. To the FEDER-Interreg España-Portugal programme for financial support through the project TRANSCoLAB 0612_TRANS_CO_LAB_2_P and to ERDF through the Regional Operational Program North 2020, within the scope of the Project GreenHealth—Norte-01-0145- FEDER-000042. The authors are also grateful to the Ministry of Education, Science and Technological Development, Republic of Serbia, grant No. 173032.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationAñibarro-Ortega, Mikel; Pinela, José; Ćirić, Ana; Lopes, Elsa; Molina, Adriana K.; Calhelha, Ricardo C.; Soković, Marina; Ferreira, Olga; Ferreira, Isabel C.F.R.; Barros, Lillian (2021). Extraction of aloesin from aloe vera rind using alternative green solvents: Process optimization and biological activity assessment. Biology. ISSN 2079-7737. 10:10, p. 1-16en_EN
dc.identifier.doi10.3390/biology10100951en_EN
dc.identifier.issn2079-7737
dc.identifier.urihttp://hdl.handle.net/10198/24270
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.relationNot Available
dc.subjectAloesinen_EN
dc.subjectAloevera green rinden_EN
dc.subjectAntimicrobial activityen_EN
dc.subjectAntioxidant activityen_EN
dc.subjectAqueous glycolic solventsen_EN
dc.subjectCytotoxicityen_EN
dc.subjectProcess optimizationen_EN
dc.titleExtraction of aloesin from aloe vera rind using alternative green solvents: Process optimization and biological activity assessmenten_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F01011%2F2018%2FCP1578%2FCT0002/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FEQU-EPQ%2F30463%2F2017/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2018
oaire.fundingStream9471 - RIDTI
person.familyNameAñibarro-Ortega
person.familyNamePinela
person.familyNameMolina
person.familyNameCalhelha
person.familyNameFerreira
person.familyNameFerreira
person.familyNameBarros
person.givenNameMikel
person.givenNameJosé
person.givenNameAdriana K.
person.givenNameRicardo C.
person.givenNameOlga
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.identifier144781
person.identifier469085
person.identifier.ciencia-idC61D-DD88-73C7
person.identifier.ciencia-id771C-2B43-B108
person.identifier.ciencia-idC110-0167-E58D
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9F1D-C75A-4A54
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-2835-5079
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0002-6234-2212
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-8414-3479
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridB-4466-2014
person.identifier.ridJ-2172-2014
person.identifier.ridM-4567-2013
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id57203083219
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication7235cb7a-09a1-453b-b39b-52989046fab6
relation.isAuthorOfPublication706cd9ff-065b-4c98-98a7-5c0a9e45adc4
relation.isAuthorOfPublicationdc9b5b67-c45e-4fbe-8af1-8cec9adb5cd9
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isAuthorOfPublication59e0c608-0c21-4191-af5e-529d21970399
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscoverydc9b5b67-c45e-4fbe-8af1-8cec9adb5cd9
relation.isProjectOfPublication29718e93-4989-42bb-bcbc-4daff3870b25
relation.isProjectOfPublicationec142c57-5163-4512-9a14-7319866da393
relation.isProjectOfPublication306b8c40-2340-4c47-99e5-f710ac8a46eb
relation.isProjectOfPublication.latestForDiscoveryec142c57-5163-4512-9a14-7319866da393

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
14.pdf
Size:
3.7 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Plain Text
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus