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Comparative antioxidant and antimicrobial properties of Lentinula edodes Donko and Koshin varieties against priority multidrug-resistant pathogens

2021Journal article Open access
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dc.contributor.authorGarcia, Juliana
dc.contributor.authorAfonso, Ana Cristina
dc.contributor.authorFernandes, Conceição
dc.contributor.authorNunes, Fernando M.
dc.contributor.authorMarques, Guilhermina
dc.contributor.authorSaavedra, Maria José
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-22T15:11:49Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-22T15:11:49Z
dc.date.issued2021
dc.description.abstractThe problematic increase in multidrug-resistant bacteria translates into the urgent need to discover novel and effective antimicrobial substances. Herein, mushrooms could be a promising alternative of natural source of new antimicrobials. The present work aimed to compare the phytochemical composition and antimicrobial activity of methanol and aqueous crude extracts of Lentinula edodes var. Koshin and Donko. Disk diffusion method was used to screen the antimicrobial activity and to assess the synergistic effect of the mushroom extracts. Microdilution method was used to determine the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). Phytochemical characterization of mushrooms extracts was achieved by analysis of total phenols, ortho-diphenols content and its antioxidant activity. The results noticed a positive relation between phenolic compounds content, antioxidant activity, and antimicrobial capacity of the mushroom's extracts. The L. edodes var. Koshin aqueous extracts, which contained the highest amount of total phenolic compounds, exhibited the highest scavenging capacity of ABTS which, in turns, exhibited the highest antimicrobial efficacy in inhibiting the growth of methicillin-resistant Staphylococcus aureus. Moreover, the combination between mushrooms extracts and commercial antibiotics showed favorable synergistic effects against tested bacteria. These results suggest that L. edodes var. Koshin may represent an important and valuable therapeutic source of compounds to be used against multidrug-resistant bacteria.en_EN
dc.description.sponsorshipThis work was supported by the project I&T Companies in Co- Promotion FungiTech, Norte-01-0247-FEDER-033788; National Funds by FCT - Portuguese Foundation for Science and Technology, under the project UIDB/04033/2020 (CITAB-Center for the Research and Technology of Agro-Environmental and Biological Sciences), Centro de Química – Vila Real (UIDB/00616/2020) and UIDB/00690/2020 (CIMO-Centro de Investigaç˜ao de Montanha).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationGarcia, Juliana; Afonso, Ana; Fernandes, Conceição; Nunes, Fernando M.; Marques, Guilhermina; Saavedra, Maria José (2021). Comparative antioxidant and antimicrobial properties of Lentinula edodes Donko and Koshin varieties against priority multidrug-resistant pathogens. South African Journal of Chemical Engineering. ISSN 1026-9185. 35, p. 98-106en_EN
dc.identifier.doi10.1016/j.sajce.2020.09.008en_EN
dc.identifier.issn1026-9185
dc.identifier.urihttp://hdl.handle.net/10198/24287
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationChemistry Center - Vila Real
dc.relationMountain Research Center
dc.subjectAntibiotic resistanceen_EN
dc.subjectDonkoen_EN
dc.subjectKlebsiella pneumoniaeen_EN
dc.subjectKoshinen_EN
dc.subjectShiitakeen_EN
dc.subjectStaphylococcus aureusen_EN
dc.titleComparative antioxidant and antimicrobial properties of Lentinula edodes Donko and Koshin varieties against priority multidrug-resistant pathogensen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleChemistry Center - Vila Real
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00616%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFernandes
person.givenNameConceição
person.identifier15483
person.identifier.ciencia-id6514-3D41-4534
person.identifier.orcid0000-0003-2873-501X
person.identifier.scopus-author-id23018336600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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relation.isAuthorOfPublication.latestForDiscoveryd9c26c54-5e10-4ccb-b7f7-528af9eb9950
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relation.isProjectOfPublication0619ae71-c932-4352-89e7-fd0add0939fa
relation.isProjectOfPublication29718e93-4989-42bb-bcbc-4daff3870b25
relation.isProjectOfPublication.latestForDiscovery0619ae71-c932-4352-89e7-fd0add0939fa

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