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Nutritional, antioxidant and antitumour properties of Leccinum vulpinum Watling

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dc.contributor.authorReis, Filipa S.
dc.contributor.authorSousa, Diana
dc.contributor.authorBarros, Lillian
dc.contributor.authorMartins, Anabela
dc.contributor.authorMorales, Patricia
dc.contributor.authorVasconcelos, M. Helena
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2015-11-04T10:05:27Z
dc.date.available2015-11-04T10:05:27Z
dc.date.issued2014
dc.description.abstractMushrooms are widely appreciated all over the world for their nutritional [1] and bioactive properties [2, 3]. This work characterizes Leccinum vulpinum Watling, an edible mushroom harvested in Bragan<;:a's outskirts (Northeastern Portugal), a region with a great mycological biodiversity. The samples were chemically characterized regarding their content in nutrients and non-nutrients. Furthermore, the antioxidant and antitumour properties of the methanolic extract were evaluated. The nutritional value was assessed through the composition in macronutrients following standard procedures; the individual profiles in sugars, fatty acids, tocopherols, phenolic and organic acids were evaluated through chromatographic techniques. The antioxidant capacity was evaluated though the reducing power, radical-scavenging activity and lipid peroxidation inhibition of the samples. The screening for tumour cell growth inhibitory activity was carried out in four human tumour cell lines: AGS (gastric adenocarcinoma), MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and HCT-15 (colorectal adenocarcinoma). The activity of the extract was further studied in the most sensitive cells (HCT-15), particularly regarding its effects on the cell cycle profile (by flow cytometry). L. vulpinum species may be considered a healthy food, with a great nutritional value, being a source of nutraceuticals (e.g., mono- and polyunsaturated fatty acids, and vitamins) and other bioactive compounds (e.g., phenolic acids). This species also showed antioxidant activity. Concerning the antitumour properties, L. vulpinum inhibited the growth of the tested cell lines. Additionally, treatment of HCT-15 cells (the most sensitive cell line) with 77.2 flg/mL of this extract caused a statistically significant increase in the S phase and a decrease in the G2/M phase of the cell cycle.pt_PT
dc.identifier.citationReis, Filipa S.; Sousa, Diana; Barros, Lillian; Martins, Anabela; Morales, Patricia; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R. (2014). Nutritional, antioxidant and antitumour properties of Leccinum vulpinum Watling. In XX Encontro Luso-Galego de Química. Porto. ISBN 978-989-98541-7-8pt_PT
dc.identifier.urihttp://hdl.handle.net/10198/12261
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationPEstOE/AGR/UI0690/2011pt_PT
dc.relationNORTE-07-0124-FEDER-000023pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleNutritional, antioxidant and antitumour properties of Leccinum vulpinum Watlingpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.titleXX Encontro Luso-Galego de Químicapt_PT
person.familyNameReis
person.familyNameBarros
person.familyNameMartins
person.familyNameFerreira
person.givenNameFilipa S.
person.givenNameLillian
person.givenNameAnabela
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id391F-AFE1-64C7
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id7B18-A810-6B93
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9159-0530
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-6218-4413
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridI-2093-2013
person.identifier.ridJ-3600-2013
person.identifier.ridG-5488-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36982144400
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id7203013518
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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