Orientador(es)
Resumo(s)
The surfactant-free nature and higher stability of Pickering emulsions make them preferable solutions over conventional
emulsions for skin applications. In this work, Pickering emulsions stabilized by chitosan/gum Arabic
(CH/GA) nanoparticles were tested as vehicles for trans-resveratrol topical delivery. Skin absorption was examined
ex vivo using Franz diffusion cells and porcine skin. Pickering emulsions allowed higher cutaneous retention
and lower permeation of resveratrol, in comparison with a control solution based on a 20% v/v ethanol. The total
amount of resveratrol retained in the skin, 24 h after the application, was 11.60% and 10.82% of the applied dose
for the tested Pickering emulsion-based formulations prepared with 0.5% and 1.5%w/v CH/GA nanoparticles, respectively.
In contrast, resveratrol skin retention from the control solution was only 2.86%. Confocal laser scanning
microscopy revealed enhanced skin deposition of Nile Red to deeper layers from the Pickering emulsionbased
formulations. Moreover, Pickering emulsions led to trans-resveratrol photostability increase, as measured
after exposure to UV for 4 h. These results show that the CH/GA Pickering emulsions are promising solutions for
the topical delivery of trans-resveratrol and have the potential to be used as green cosmetic products.
Descrição
Palavras-chave
Biodegradable Chitosan/gum Arabic nanoparticles Photostability Pickering emulsions Resveratrol Topical delivery
Contexto Educativo
Citação
Sharkawy, Asma; Casimiro, Filipa M.; Barreiro, Maria Filomena; Rodrigues, Alírio E. (2020). Enhancing trans-resveratrol topical delivery and photostability through entrapment in chitosan/gum Arabic Pickering emulsions. International Journal of Biological Macromolecules. ISSN 0141-8130. 147, p. 150-159