Repository logo
 
Publication

Effects of gamma radiation on chemical and antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity of borututu

2014Journal article Open access
Simple item page
dc.contributor.authorPereira, Carla
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorAntonio, Amilcar L.
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2015-08-03T14:29:05Z
dc.date.available2015-08-03T14:29:05Z
dc.date.issued2014
dc.description.abstractBorututu is a well-known medicinal plant in Angola for the treatment of liver diseases and for the prophylaxis of malaria. Our research group reported, in a recent study, that its infusion, pills and syrups display significant antioxidant and anti-hepatocellular carcinoma activities. However, during the processing and storage, it can be easily exposed to contamination that can lead to a microbial deterioration or insect infestation compromising its quality, shelf life, and efficiency. Herein, we investigated the effect of gamma irradiation, one of the most promising decontamination methods for many foodstuffs and plant materials, at different doses (1 and 10 kGy) on borututu regarding to its nutritional value, lipophilic (fatty acids and tocopherols) and hydrophilic (free sugars and organic acids) compounds, antioxidant and anti-hepatocellular carcinoma activities. In general, the irradiation treatment did not appreciably affect the nutritional value of the studied plant, but the highest energetic contribution (383.83 kcal/100 g), total sugars (8.63 g/100 g), organic acids (3.31 g/100 g dw), total tocopherols (336.72 mg/100 g dw), and PUFA (32.75%) contents were found in the sample irradiated at 10 kGy. Furthermore, this sample presented also the highest levels of total phenolics and flavonoids and, in general, the highest antioxidant activity (EC50 values of 0.04 to 0.24 mg/mL for the methanolic extract and 0.03 to 1.34 mg/mL for the infusion). Irradiated samples kept the anti-hepatocellular carcinoma activity, but a decrease was observed in the methanolic extract prepared from sample irradiated at 10 kGy (GI50=188.97 µg/mL). Overall, gamma irradiation proved to be a suitable technique of preservation of dried herbs without affecting the bioactive compounds.por
dc.description.sponsorshipThe authors thank Clarinda Paixão, from Américo Duarte Paixão Lda, for samples providing.por
dc.identifier.citationPereira, Carla; Calhelha, Ricardo C.; Antonio, Amilcar L.; Queiroz, Maria João R.P.; Barros, Lillian; Ferreira, Isabel C.F.R. (2014). Effects of gamma radiation on chemical and antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity of borututu. Innovative Food Science and Emerging Technologies. ISSN 1466-8564. 26, p. 271-277por
dc.identifier.doi10.1016/j.ifset.2014.05.010
dc.identifier.issn1466-8564
dc.identifier.urihttp://hdl.handle.net/10198/12031
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectGamma irradiationpor
dc.subjectBorututupor
dc.subjectHydrophilic compoundspor
dc.subjectLipophilic compoundspor
dc.subjectAntioxidant activitypor
dc.subjectHepG2por
dc.titleEffects of gamma radiation on chemical and antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity of borututupor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage277por
oaire.citation.startPage271por
oaire.citation.titleInnovative Food Science and Emerging Technologiespor
oaire.citation.volume26por
person.familyNamePereira
person.familyNameCalhelha
person.familyNameAntonio
person.familyNameBarros
person.familyNameFerreira
person.givenNameCarla
person.givenNameRicardo C.
person.givenNameAmilcar L.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier1415151
person.identifier469085
person.identifier144781
person.identifier.ciencia-idEF10-2739-2B70
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id1014-5259-DE86
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-0093-771X
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-8271-9964
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridK-1629-2016
person.identifier.ridJ-2172-2014
person.identifier.ridJ-1960-2014
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id55627876424
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id44560921900
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicatione07a8e12-52bb-47c5-bae7-41a5f648213b
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isAuthorOfPublication4b23e496-8d11-4ff5-a8ec-e1c2235e5a28
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoverye07a8e12-52bb-47c5-bae7-41a5f648213b

Files

Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
236.pdf
Size:
252.87 KB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
1-s2.0-S1466856414000812-main.pdf
Size:
268.42 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus