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Nutritional values, chemical characterization and cytotoxicity in human tumor cell lines of desert truffles

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dc.contributor.authorAmara, Khira
dc.contributor.authorReis, Filipa S.
dc.contributor.authorBarros, Lillian
dc.contributor.authorSkhiri, Fethia
dc.contributor.authorMartins, Anabela
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-03-05T11:18:19Z
dc.date.available2018-03-05T11:18:19Z
dc.date.issued2017
dc.description.abstractMushrooms are widely appreciated for their nutritional value, as well as for their health promoting properties [1,2]. Due to their proven bioactive potential, their application in food (e.g., incorporation of mushroom extracts in food products and functional foods) and pharmaceutical (e.g., nutraceuticals and food supplements incorporating mushrooms) industries, or the cosmetics industry (e.g., antiaging products) has been explored [3-5]. The present work intends to determine the chemical and nutritional composition, as also to evaluate the cytotoxicity of samples from a mushroom genus commonly known as desert truffles – Terfezia. To this end, three different species were studied, namely Terfezia arenaria (Moris) Trappe, Terfezia magnusii Mattir., and Terfezia leptoderma Tul. The nutritional value (protein, fat, carbohydrates and energetic value) of the species was evaluated following standard procedures, and their content in hydrophilic compounds (e.g., soluble sugars, phenolic and other organic acids) and lipophilic compounds (e.g., fatty acids and tocopherols) was assessed by chromatographic techniques (High Performance Liquid Chromatography and Gas Chromatography). The cytotoxic potential of the samples was also evaluated, testing the mushroom species against a panel of human tumor cell lines (MCF7- breast carcinoma, HeLa- cervical carcinoma, NCI-H460- non-small cell lung carcinoma and HepG2- hepatocellular carcinoma) and against porcine liver primary cells (PLP2). All samples proved to have high contents in carbohydrates and proteins, being low fat products. Mannitol and trehalose were the main sugars found, being also present bioactive phenolic acids. Among the lipophilic compounds, linoleic, oleic and plamitic acids were the major fatty acids present in the samples, together with different tocopherol vitamers. None of the samples showed cytotoxicity against non-tumor cells being in course the bioassays with human tumor cell lines. Overall, desert truffles proved to be highly nutritional species with bioactive compounds and potential to be used as cytotoxic agents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAmara, Khira; Reis, Filipa S.; Barros, Lillian; Skhiri, Fethia; Martins, Anabela; Ferreira, Isabel C.F.R. (2017). Nutritional values, chemical characterization and cytotoxicity in human tumor cell lines of desert truffles. In 8es Journées Scientifiques Internationales sur la Valorisation des Bioressources. Monastirpt_PT
dc.identifier.urihttp://hdl.handle.net/10198/16164
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTerfezia spp.pt_PT
dc.subjectChemical compositionpt_PT
dc.subjectNutrientspt_PT
dc.subjectCytotoxicity propertiespt_PT
dc.titleNutritional values, chemical characterization and cytotoxicity in human tumor cell lines of desert trufflespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceMonastir, Tunisiapt_PT
oaire.citation.title8es Journées Scientifiques Internationales sur la Valorisation des Bioressourcespt_PT
person.familyNameReis
person.familyNameBarros
person.familyNameMartins
person.familyNameFerreira
person.givenNameFilipa S.
person.givenNameLillian
person.givenNameAnabela
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id391F-AFE1-64C7
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id7B18-A810-6B93
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9159-0530
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-6218-4413
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridI-2093-2013
person.identifier.ridJ-3600-2013
person.identifier.ridG-5488-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36982144400
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id7203013518
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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relation.isAuthorOfPublication.latestForDiscoveryb8d384ae-2134-4735-93a6-0d2febbf9220

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