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How does the maturation state of cardoon bracts influence its phenolic composition and bioactivity?

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dc.contributor.authorMandim, Filipa
dc.contributor.authorPetropoulos, Spyridon Α.
dc.contributor.authorPinela, José
dc.contributor.authorDias, Maria Inês
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2022-01-20T15:11:43Z
dc.date.available2022-01-20T15:11:43Z
dc.date.issued2021
dc.description.abstractCynara cardunculus L. (cardoon) is an herbaceous plant native to the Mediterranean basin. It is widely used due to its nutritional, pharmacological, and industrial applications [1]. Besides its consumption in various recipes, due to its rich nutritional composition and health-promoting effects, it is also widely used in several industry sectors (e.g., cheese manufacturing, and in the production of pharmaceuticals, bioenergy, and biomass). Its multiple applications are extremely important for the enhancement of the species‘ added value [2]. However, factors such as genetic information, plant tissue, and maturity state can influence the potential of the species [1,2]. The study of the influence of all these variables is extremely important for its proper use, as well for its economic valorisation. Cardoon bracts were collected in Greece at eight harvesting dates (Principal Growth Stage between 5 and 8/9). The phenolic composition of their hydroethanolic extracts was analysed by HPLC-DAD-ESI/MS. The antioxidant activity was evaluated with two cell-based assays: thiobarbituric acid reactive substances (TBARS) formation inhibition and oxidative haemolysis assay (OxHLIA). The anti-inflammatory activity was evaluated by determining the extracts‘ ability to inhibit nitric oxide production in a murine macrophage cell line. Finally, cytotoxicity was assessed against four human tumour cell lines and a porcine liver primary cell culture using the sulforhodamine B assay. Twelve phenolic compounds were tentatively identified, with 3,5-O-dicaffeoylquinic acid and apigenin-7-O-glucuronide being the major compounds detected. Immature bracts presented the highest phenolic compounds content, as also the highest anti-inflammatory and cytotoxic activities. Regarding the antioxidant activity, immature bracts revealed the highest ability to inhibit the formation of TBARS. For OxHLIA, cardoon bracts harvested at more advanced maturation stages were the ones that revealed the highest activity. In conclusion, it was verified that the maturation stage influences the phenolic composition and the biological potential of cardoon bracts. However, more studies are needed to understand and correlate the compounds responsible with the observed bioactivities.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020); to the national funding by FCT, P.I., through the institutional scientific employment program-contract for M.I. Dias and L. Barros, and individual scientific employment program-contract to J. Pinela (CEECIND/01011/2018); for F. Mandim PhD grant (SFRH/BD/146614/2019); to FEDER through the Regional Operational Program North 2020, under the Project GreenHealth (Norte-01-0145-FEDER-000042).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMandim, Filipa; Petropoulos, Spyridon A.; Pinela, José; Dias, Maria Inês; Santos Buelga, Celestino; Ferreira, Isabel C.F.R.; Barros, Lillian (2020). How does the maturation state of cardoon bracts influence its phenolic composition and bioactivity? In 5th International Symposium on Phytochemicals in Medicine and Food. Nanchang, China
dc.identifier.urihttp://hdl.handle.net/10198/24801
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCEECIND/01011/2018pt_PT
dc.relationMountain Research Center
dc.relationIntegrated strategies for the development of a novel functional beverage with sustainable production systems
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCardoonpt_PT
dc.subjectCynara cardunculus L. (cardoon)pt_PT
dc.titleHow does the maturation state of cardoon bracts influence its phenolic composition and bioactivity?pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardNumberUIDB/00690/2020
oaire.awardNumberSFRH/BD/146614/2019
oaire.awardTitleMountain Research Center
oaire.awardTitleIntegrated strategies for the development of a novel functional beverage with sustainable production systems
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F146614%2F2019/PT
oaire.citation.conferencePlaceNachang University, Chinapt_PT
oaire.citation.title5th International Symposium on Phytochemicals in Medicine and Foodpt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMandim
person.familyNamePinela
person.familyNameDias
person.familyNameFerreira
person.familyNameBarros
person.givenNameFilipa
person.givenNameJosé
person.givenNameMaria Inês
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.identifier144781
person.identifier469085
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person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridB-4466-2014
person.identifier.ridM-8242-2013
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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