Publication
Effect of chronic therapy with chaethomellic acid A on renal fibrosis in 5/6 nephrectomized rats: a preliminary study
| dc.contributor.author | Nogueira, António José M. | |
| dc.contributor.author | Vala, Helena | |
| dc.contributor.author | Nóbrega, Carmen | |
| dc.contributor.author | Pires, Carlos André | |
| dc.contributor.author | Colaço, Bruno Jorge | |
| dc.contributor.author | Oliveira, Paula A. | |
| dc.contributor.author | Pires, Maria João | |
| dc.date.accessioned | 2018-03-19T17:39:38Z | |
| dc.date.available | 2018-03-19T17:39:38Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | The high prevalence of chronic kidney disease underscores the failure to provide therapies to effectively halt, prevent, and/or reverse renal fibrosis. Thus, the aim of this study was to evaluate the effect of chronic treatment with chaethomellic acid A (CA) on renal fibrosis associated to 5/6 nephrectomy. Methods: Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats were placed in four experimental groups: RMR: rats without treatment (n=13); RMR+CA: rats treated with CA (n=13); SO: rats without treatment (n=13); SO+CA: rats treated with CA (n=13). CA was intraperitoneally administered in a dose of 0.23 µg/Kg three times a week for six months. Renal samples were scored for the following lesions: glomerulosclerosis, interstitial fibrosis, arteriolosclerosis and interstitial inflammation. Results: Animals from the SO and SO+CA groups presented no kidney histological changes. Glomerulosclerosis, interstitial fibrosis and arteriolosclerosis scores were significantly lower (p< 0.001) in RMR+CA group when compared with RMR group. There were no significantly differences in interstitial inflammation score between RMR+CA and RMR groups. Conclusions: This preliminary data suggests that pharmacological inhibition of Ras (small GTPase proteins) activation may be a future strategy in the prevention of renal fibrosis. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Nogueira, António; Vala, Helena; Nóbrega, Carmen; Pires, Carlos; Colaço, Bruno; Oliveira, Paula; Pires, Maria (2015). Effect of chronic therapy with chaethomellic acid A on renal fibrosis in 5/6 nephrectomized rats: a preliminary study. In Virchows Arch. p. 1:1. ISSN 0945-6317 | pt_PT |
| dc.identifier.doi | 10.1007/s00428-015-1805-9 | pt_PT |
| dc.identifier.issn | 0945-6317 | |
| dc.identifier.uri | http://hdl.handle.net/10198/16397 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Chaethomellic acid A (CA) | pt_PT |
| dc.subject | 5/6 nephrectomy model | pt_PT |
| dc.title | Effect of chronic therapy with chaethomellic acid A on renal fibrosis in 5/6 nephrectomized rats: a preliminary study | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 279 | pt_PT |
| oaire.citation.issue | S1 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.volume | 467 | pt_PT |
| person.familyName | Nogueira | |
| person.givenName | António José M. | |
| person.identifier.ciencia-id | 8A11-794E-36BD | |
| person.identifier.orcid | 0000-0001-8912-7355 | |
| person.identifier.scopus-author-id | 55865568268 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isAuthorOfPublication | 648209a2-eec9-4bec-975a-32673e41b95c | |
| relation.isAuthorOfPublication.latestForDiscovery | 648209a2-eec9-4bec-975a-32673e41b95c |
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