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Saponin-based natural nanoemulsions as alpha-tocopherol delivery systems for dermal applications

2023Journal article Open access
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dc.contributor.authorSchreiner, Tatiana B.
dc.contributor.authorSantamaria-Echart, Arantzazu
dc.contributor.authorColucci, Giovana
dc.contributor.authorPlasencia, Paula
dc.contributor.authorCosta, Patrícia Santos
dc.contributor.authorDias, Madalena M.
dc.contributor.authorPinho, Simão
dc.contributor.authorBarreiro, M.F.
dc.date.accessioned2023-12-18T09:51:56Z
dc.date.available2023-12-18T09:51:56Z
dc.date.issued2023
dc.description.abstractNanoemulsions can be produced using simple methods and compounds from natural sources. They can increase water dispersibility and bioavailability and optimise active ingredient dispersion in particular skin layers. Lipophilic compounds of the vitamin E family (tocopherols and tocotrienols) are well-known for their high antioxidant activity and capacity to protect the skin from oxidative stress. In this context, oil-in-water (o/w) nanoemulsions with and without α-tocopherol (Vitamin E, VE) were formulated with two emulsifier alternatives, Quillaja saponin (QS), and a combination of QS with Tribulus terrestris (QSTT) (50/50, w/w). The emulsions were evaluated concerning stability, microstructure, droplet size, colour attributes, encapsulation efficiency, UV photostability, antioxidant activity, and in vitro permeation studies to assess the delivery potential. Results showed highly stable systems, with round-shape droplets of 80–121 nm size. QS and QSTT samples’ colours were close to white and light brownish, respectively. The topical nano cream had the capacity to entrap VE, producing a protective effect from UV degradation, and very significant antioxidant activity, with IC50 values around 0.01 %wt. The skin permeation profiles showed the efficiency of the formulations in the delivery of VE, with permeabilities between 64 and 74 μg/cm2, while the control sample showed no VE permeation.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/ 2020), SusTEC (LA/P/0007/2021), LSRE-LCM (UIDB/50020/2020 and UIDP/00690/2020), and ALiCE (LA/P/0045/2020). FCT for the PhD research grants of T.B. Schreiner (2020.05564.BD) and G. Colucci (2021.05215.BD). National funding by FCT, P.I., through the institutional scientific employment program contract of A. Santamaria-Echart.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSchreiner, Tatiana B.; Santamaria-Echart, Arantzazu; Colucci, Giovana; Plasencia, Paula; Costa, Patrícia Santos; Dias, Madalena M.: Pinho, Simão; Barreiro, M.F. (2023). Saponin-based natural nanoemulsions as alpha-tocopherol delivery systems for dermal applications. Journal of Molecular Liquids. ISSN 0167-7322. 391, p. 1-12pt_PT
dc.identifier.doi10.1016/j.molliq.2023.123371pt_PT
dc.identifier.eissn1873-3166
dc.identifier.issn0167-7322
dc.identifier.urihttp://hdl.handle.net/10198/28954
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationLA/P/0007/2021pt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationALICE - Associate Laboratory in Chemical Engineering
dc.relationLignin-based Pickering stabilisers for innovative cosmeceutical formulations
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSaponinpt_PT
dc.subjectTribulus terrestrispt_PT
dc.subjectQuillaja barkpt_PT
dc.subjectVitamin Ept_PT
dc.subjectBioavailabilitypt_PT
dc.subjectFranz cellspt_PT
dc.titleSaponin-based natural nanoemulsions as alpha-tocopherol delivery systems for dermal applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleALICE - Associate Laboratory in Chemical Engineering
oaire.awardTitleLignin-based Pickering stabilisers for innovative cosmeceutical formulations
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0045%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2021.05215.BD/PT
oaire.citation.endPage12pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Molecular Liquidspt_PT
oaire.citation.volume391pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSchreiner
person.familyNameSantamaria-Echart
person.familyNameColucci
person.familyNamePlasencia
person.familyNamePinho
person.familyNameBarreiro
person.givenNameTatiana B.
person.givenNameArantzazu
person.givenNameGiovana
person.givenNamePaula
person.givenNameSimão
person.givenNameFilomena
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person.identifier.orcid0000-0002-8715-5843
person.identifier.orcid0000-0001-5827-8249
person.identifier.orcid0000-0002-9211-857X
person.identifier.orcid0000-0002-6844-333X
person.identifier.ridD-4148-2013
person.identifier.ridL-9802-2014
person.identifier.scopus-author-id56725697700
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person.identifier.scopus-author-id57188719717
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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