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Flow visualizations in a PDMS cerebral aneurysm biomodel

2023Conference paper Open access
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dc.contributor.authorSouza, Andrews Victor Almeida
dc.contributor.authorFerrera, Conrado
dc.contributor.authorPuga, Hélder
dc.contributor.authorLima, Rui A.
dc.contributor.authorRibeiro, J.E.
dc.contributor.authorSouza, Maria Sabrina
dc.date.accessioned2023-01-04T11:16:09Z
dc.date.available2023-01-04T11:16:09Z
dc.date.issued2023
dc.description.abstractCerebral aneurysm is an abnormal dilatation of the blood vessel which affects a high percentage of the worldwide population. One way to investigate this pathology is using in vivo techniques, but these types of experiments have a high cost and low reproducibility. Thus, to understand the local hemodynamics of brain aneurysms, it is imperative to manufacture in vitro models that simulate real brain aneurysms. These biomodels are suitable for experimental testing, as well as for evaluating and validating computational models. In this work, was manufactured a biomodel of a cerebral aneurysm made by polydimethylsiloxane (PDMS), combining rapid prototyping technology with a PDMS gravity casting process. Experimental flow visualizations were performed at different flow rates. The flow visualizations results have shown that there is a transition from laminar to turbulent flow for a flow rate near 6 ml/min. The proposed PDMS biomodels have shown the ability to perform flow visualizations and have the potential to help the development and validation of computational models.pt_PT
dc.description.sponsorshipThe authors acknowledge the financial support provided by Fundação para a Ciência e a Tecnologia (FCT), through the projects EXPL/EME-EME/0732/2021, PTDC/EEI- EEE/2846/2021, funded by NORTE 2020, PORTUGAL2020, and FEDER. This work was also supported by Fundação para a Ciência e a Tecnologia (FCT) under the strategic grants UIDB/04077/2020, UIDB/00690/2020, UIDB/04436/2020 and UIDB/00532/2020. Andrews Souza acknowledges the PhD scholarship 2021.07961.BD attributed by FCT. Partial support from the Junta de Extremadura through Grants No. GR21091 and IB20105 (partially financed by FEDER funds) is gratefully acknowledged.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSouza, Andrews; Souza, Maria Sabrina; Ferrera, Conrado; Puga, Hélder; Lima, Rui; Ribeiro, J.E. (2023). Flow visualizations in a PDMS cerebral aneurysm biomodel. In Second International Scientific Conference (ICIE’2022). Guimarães. p. 209-215. ISBN 978-3-031-09381-4
dc.identifier.doi10.1007/978-3-031-09382-1_18pt_PT
dc.identifier.isbn978-3-031-09381-4
dc.identifier.isbn978-3-031-09382-1 (eBook)
dc.identifier.urihttp://hdl.handle.net/10198/26273
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer
dc.relationMultiplexed micro(bio)sensors array integrated into an organ-on-a-chip device for assessing cancer NANOtherapy
dc.relationMechanical Engineering and Resource Sustainability Center
dc.relationMountain Research Center
dc.relationMicroelectromechanical Systems Research Unit
dc.relationTransport Phenomena Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCerebral aneurysmpt_PT
dc.subjectIn vitro testspt_PT
dc.subjectPDMS flow biomodelspt_PT
dc.titleFlow visualizations in a PDMS cerebral aneurysm biomodelpt_PT
dc.typeconference paper
dspace.entity.typePublication
oaire.awardTitleMultiplexed micro(bio)sensors array integrated into an organ-on-a-chip device for assessing cancer NANOtherapy
oaire.awardTitleMechanical Engineering and Resource Sustainability Center
oaire.awardTitleMountain Research Center
oaire.awardTitleMicroelectromechanical Systems Research Unit
oaire.awardTitleTransport Phenomena Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FEME-EME%2F0732%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEEI-EEE%2F2846%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04077%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04436%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00532%2F2020/PT
oaire.citation.conferencePlaceGuimarães, Portugalpt_PT
oaire.citation.endPage215pt_PT
oaire.citation.startPage209pt_PT
oaire.citation.titleSecond International Scientific Conference (ICIE’2022)pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRibeiro
person.givenNameJ.E.
person.identifierR-000-6Y8
person.identifier.ciencia-id0F15-FB62-29DB
person.identifier.orcid0000-0001-6300-148X
person.identifier.ridG-3839-2018
person.identifier.scopus-author-id25638652400
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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