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Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract

2017Journal article Open access
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dc.contributor.authorStojković, Dejan
dc.contributor.authorKovačević-Grujičić, Nataša
dc.contributor.authorReis, Filipa S.
dc.contributor.authorDavidović, Slobodan
dc.contributor.authorBarros, Lillian
dc.contributor.authorPopović-Djordjević, Jelena
dc.contributor.authorPetrović, Isidora
dc.contributor.authorPavić, Aleksandar
dc.contributor.authorGlamočlija, Jasmina
dc.contributor.authorĆirić, Ana
dc.contributor.authorStevanović, Milena
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorSoković, Marina
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-01-30T15:00:25Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-01-30T15:00:25Z
dc.date.issued2017
dc.description.abstractWild Meripilus giganteus Karst belongs to the order Polyporales, in which some members are known to possess a wide range of pharmacological properties. M. giganteus showed to be rich in carbohydrates (74.49 g/100 g) and proteins (15.94 g/100 g), presenting low fat content (1.51 g/100 g). Chemical composition was determined by using chromatographic techniques. Also, various bioactive compounds were detected including all four tocopherol isoforms with d- and ?-tocopherols being predominant (123.35 and 77.80 µg/100 g, respectively); five organic acids (oxalic, malic, quinic, citric and fumaric acids) with predominant malic acid (3.17 g/100 g); and three phenolic acids and related compounds (p-hydroxybenzoic, p-coumaric and cinnamic acids; 1010, 2420 and 340 µg/100 g, respectively). M. giganteus methanolic extract exhibited antioxidant activity tested by five different assays with the strongest potential in TBARS assay (EC 50 0.31 mg/mL); and antimicrobial activities (MIC/MBC 0.0125–5 mg/mL; MIC/MFC 0.025–0.4 mg/mL). Furthermore, treatment of cervical carcinoma cell line (HeLa) led to reduction in cell's viability in MTT assay (IC 50 0.41 mg/mL after 48 h), induced process of apoptosis and inhibited cell's migration in vitro. The analysed extract was not toxic for zebrafish embryos (at 0.5 mg/mL), indicating its biosafety and potential application as a dietary supplement in chemoprevention.pt_PT
dc.description.sponsorshipThis work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (grant numbers 173032, 173051 and 47025). Authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support to CIMO (Pest-OE/AGR/UI0690/2015) and L. Barros grant (SFRH/BPD/107855/2015). We would like to thank dr Jelena Dinic for help in performing DAPI/PI staining.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationStojković, Dejan; Kovačević-Grujičić, Nataša; Reis, Filipa S.; Davidović, Slobodan; Barros, Lillian; Popović, Jelena; Petrović, Isidora; Pavić, Aleksandar; Glamočlija, Jasmina; Ćirić, Ana; Stevanović, Milena; Ferreira, Isabel C.F.R.; Soković, Marina (2017). Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract. LWT - Food Science and Technology. ISSN 0023-6438. 79, p. 454-462en_EN
dc.identifier.doi10.1016/j.lwt.2017.01.045pt_PT
dc.identifier.issn0023-6438
dc.identifier.urihttp://hdl.handle.net/10198/15294
dc.language.isoeng
dc.peerreviewedyespt_PT
dc.relation173032
dc.relation0690/2015
dc.relation107855/2015
dc.subjectAntimicrobial activityen_EN
dc.subjectAntioxidant activityen_EN
dc.subjectAntitumor activityen_EN
dc.subjectApoptosisen_EN
dc.subjectMeripilus giganteus Karsten_EN
dc.titleChemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extracten_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameReis
person.familyNameBarros
person.familyNameFerreira
person.givenNameFilipa S.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id391F-AFE1-64C7
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9159-0530
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridI-2093-2013
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36982144400
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccessen_EN
rcaap.typearticlept_PT
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relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoveryb8d384ae-2134-4735-93a6-0d2febbf9220

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