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Phenolic extracts of Fragaria vesca L. roots with anti-Candida potential: chemical characterization and in vitro antifungal capacity

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dc.contributor.authorMartins, Natália
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorSilva, Sónia
dc.contributor.authorHenriques, Mariana
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2015-11-24T11:34:01Z
dc.date.available2015-11-24T11:34:01Z
dc.date.issued2015
dc.description.abstractCandida species, considered a commensal microorganism of the human flora, have caused a profound impact at public health level. Furthermore, there are alarming numbers of microorganisms with acquired drug resistance, contributing to the inefficacy of antifungal agents [1]. Thus, efficient alteratives to the current antifungal agents and without side effects need to be discovered. Plants comprise numerous bioactive compounds responsible for a wide variety of bioactive properties. Fragaria vesca L. (wild strawberry), belongs to the Rosaceae family and its fruits are commonly used for culinary purposes. Only its leaves are used for medicinal purposes, due to the astringent (hemostatic and antidiarrheal), diuretic, depurative and tonic effects [2]. A few studies have been carried out in order to evaluate the bioactive potential of its roots [3], but to the authors knowledge, no reports are available regarding its antifungal potential against Candida species. Thus, the aim of the present study was to evaluate the antifungal potential of the hydromethanolic extract obtained from F. vesca roots, against nineteen Candida strains, belonging to C. albicans, C. glabrata, C. parapsilosis and C. tropicalis species. At the tested concentration (50 mg/mL), a most pronounced inhibitory effect was observed against C. tropicalis and C. parapsilosis (inhibitory zones varying between 9-10 and 10 mm, respectively). The obtained results remained similar after 24h, 48h and even 72h. Considering the evidenced antifungal potential, and taking into account its chemical composition, the observed effects could be attributed to the presence of phenolic compounds, such as flavan-3- ols, being (epi)catechin derivatives (mainly procyanidins) the main compounds found, as also elagic acid derivatives. Further studies should be conducted in order to identify the active principle(s) responsible for the observed effects and the corresponding mechanism of action.pt_PT
dc.identifier.citationMartins, Natália; Dias, Maria Inês; Barros, Lillian; Silva, Sónia; Henriques, Mariana; Ferreira, Isabel C.F.R. (2015). Phenolic extracts of Fragaria vesca L. roots with anti-Candida potential: chemical characterization and in vitro antifungal capacity. In 2nd Symposium on Medicinal Chemistry of University of Minhopt_PT
dc.identifier.urihttp://hdl.handle.net/10198/12382
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationNORTE-07-0124-FEDER-000027-QRENpt_PT
dc.relationPLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES
dc.relationIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titlePhenolic extracts of Fragaria vesca L. roots with anti-Candida potential: chemical characterization and in vitro antifungal capacitypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitlePLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES
oaire.awardTitleIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F87658%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F84485%2F2012/PT
oaire.citation.title2nd Symposium on Medicinal Chemistry of University of Minhopt_PT
oaire.fundingStream5876
person.familyNameDias
person.familyNameBarros
person.familyNameFerreira
person.givenNameMaria Inês
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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