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Development of chitosan microspheres through a green dual crosslinking strategy based on tripolyphosphate and vanillin

2021Journal article Open access
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dc.contributor.authorCorrea, Rodolpho Fagundes
dc.contributor.authorColucci, Giovana
dc.contributor.authorHalla, Noureddine
dc.contributor.authorPinto, João A.
dc.contributor.authorSantamaria-Echart, Arantzazu
dc.contributor.authorBlanco, Silvia Priscila
dc.contributor.authorFernandes, Isabel P.
dc.contributor.authorBarreiro, M.F.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-23T12:12:40Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-23T12:12:40Z
dc.date.issued2021
dc.description.abstractMicroencapsulation procedures have recently focused attention on designing novel mi-crospheres via green synthesis strategies. The use of chitosan (CS) as an encapsulating material has increased interest due to its unique bioactive properties and the various crosslinking possibilities offered by their functional groups. The consolidation of the microspheres by physical crosslinking using sodium tripolyphosphate (TPP) combined with chemical crosslinking using vanillin (VA) open new opportunities in the framework of green dual crosslinking strategies. The developed strategy, a straightforward technique based on an aqueous medium avoiding complex separa-tion/washing steps, offers advantages over the processes based on VA, mostly using water-in-oil emulsion approaches. Thus, in this work, the combination of TPP crosslinking (3, 5, and 10 wt.%) via spray-coagulation technique with two VA crosslinking methods (in situ and post-treatment using 1 wt.% VA) were employed in the preparation of microspheres. The microspheres were characterized concerning morphology, particle size, physicochemical properties, thermal stability, and swelling behavior. Results revealed that the combination of 5 wt.% TPP with in situ VA crosslinking led to microspheres with promising properties, being an attractive alternative for natural bioactives encapsulation due to the green connotations associated with the process.en_EN
dc.description.sponsorshipFinancial support by national funds FCT/MCTES to CIMO (UIDB/00690/2020). National funding by the FCT—Foundation for Science and Technology, through the institutional scientific employment program—contract with I.P.F. Further support was obtained through the Valor Natural project (Mobilized Project Norte-01-0247-FEDER-024479) and the GreenHealth project (Norte-01- 0145-FEDER-000042).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationCorrea, Rodolpho Fagundes; Colucci, Giovana; Halla, Noureddine; Pinto, João Alves; Santamaria-Echart, Arantzazu; Blanco, Silvia Priscila; Fernandes, Isabel Patrícia; Barreiro, Maria Filomena (2021). Development of chitosan microspheres through a green dual crosslinking strategy based on tripolyphosphate and vanillin. Molecules. ISSN 1420-3049. 26:8, p. 1-16en_EN
dc.identifier.doi10.3390/molecules26082325en_EN
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/24365
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.subjectChitosan microspheresen_EN
dc.subjectDual crosslinking strategiesen_EN
dc.subjectGreen crosslinkeren_EN
dc.subjectTripolyphos-phateen_EN
dc.subjectVanillinen_EN
dc.titleDevelopment of chitosan microspheres through a green dual crosslinking strategy based on tripolyphosphate and vanillinen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameColucci
person.familyNamePinto
person.familyNameSantamaria-Echart
person.familyNameFernandes
person.familyNameBarreiro
person.givenNameGiovana
person.givenNameJoão A.
person.givenNameArantzazu
person.givenNameIsabel P.
person.givenNameFilomena
person.identifier.ciencia-id7C17-EC19-5F05
person.identifier.ciencia-idE518-E967-5179
person.identifier.ciencia-id0C17-1E1F-2621
person.identifier.ciencia-id4D1C-441F-C7F0
person.identifier.ciencia-id3418-47D5-5746
person.identifier.orcid0000-0002-8715-5843
person.identifier.orcid0000-0002-6853-9921
person.identifier.orcid0000-0003-0107-7301
person.identifier.orcid0000-0002-0069-4503
person.identifier.orcid0000-0002-6844-333X
person.identifier.ridL-1552-2016
person.identifier.ridL-9802-2014
person.identifier.scopus-author-id57208035714
person.identifier.scopus-author-id56725697700
person.identifier.scopus-author-id26323585300
person.identifier.scopus-author-id57188719717
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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