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Flavonoid composition and in vitro anti-proliferative activity of the hydroethanolic extracts of Garcinia mangostana L. pericarp

2021Conference object Open access
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dc.contributor.authorAlbuquerque, Bianca R.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorOliveira, Beatriz
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2022-01-25T12:13:40Z
dc.date.available2022-01-25T12:13:40Z
dc.date.issued2021
dc.description.abstractGarcinia mangostana L., known as mangosteen, is a tropical fruit belonging to the Clusiaceae family, native from South Asia but can also be found in other tropical territories, such as South America [1,2,3]. The fruit comprises an inedible dark purple epicarp (> 60%) that encases an edible succulent pulp [2]. Nowadays, mangosteen pulp and pericarp have been used in beverages as food supplement by virtue of the traditional knowledge about its health benefits. However, correlation studies between the folk medicine usage and its chemical composition are scarce in the literature [2,3]. Aiming to elucidate part of the chemical composition, the present study carried out the determination of the main flavonoids, including anthocyanin compounds, present in mangosteen pericarp by High Performance Liquid Chromatography coupled to a diode array detector and mass spectrometry by electrospray ionization (HPLC-DAD-ESI/MSn). Furthermore, the cytotoxicity effects of its hydroethanolic extracts were evaluated on four human tumor cell lines (NCI-H460 - lung carcinoma, MCF-7 - breast carcinoma, HepG2 - hepatocellular carcinoma, and HeLa - cervical carcinoma) by the Sulforhodamine B (SRB) assay. Mangosteen pericarp presented nine non-anthocyanin flavonoid compounds, most of which belonging to the procyanidin class (seven compounds), one taxifolin derivative (taxifolin-O-rhamnoside, found in low concentrations), and one quercetin derivative (quercetin-3-O-rutinose, found in trace amounts). Regarding the anthocyanin flavonoids compounds group, two were found and tentatively identified as cyanidin-O- dihexoside and delphinidin-O-dihexoside. Regarding the total amount of flavonoids, the extracts presented 53 ± 1 mg of non-anthocyanin flavonoids/g of extract, 3.66 ± 0.02 mg of anthocyanins/g of extract. Concerning the cytotoxic activity, the hydroethanolic extracts presented activity against all tumor cell lines studied (GI50 < 75 μg/mL). The results obtained from the present study showed that mangosteen pericarp could be an interesting natural source of high added value and bioactive compounds, with the potential to the applied in several industrial fields including pharmaceutical, nutraceutical, among others.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020). National funding by FCT, P.I., through the individual scientific employment program- contract for M.I. Dias, R.C. Calhelha, and L. Barros contracts and B.R. Albuquerque research grant (SFRH/BD/136370/2018). This work was also funded by the European Regional Development Fund (ERDF) through the Regional Operational Program North 2020, within the scope of Project NORTE-01-0145-FEDER-023289: DeCodE and project Mobilizador Norte-01-0247-FEDER- 024479: ValorNatural®.The authors are grateful to FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E and the project TRANSCoLAB 0612_TRANS_CO_LAB_2_P.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlbuquerque, Bianca A.; Dias, Maria Inês; Calhelha, Ricardo C.; Oliveira, Beatriz; Ferreira, Isabel C.F.R.; Barros, Lillian (2021). Flavonoid composition and in vitro anti-proliferative activity of the hydroethanolic extracts of Garcinia mangostana L. pericarp. In 1st Natural products application: health, cosmetic and food: book of abstracts. Bragança: Instituto Politécnico. ISBN 978-972-745-286-6pt_PT
dc.identifier.isbn978-972-745-286-6
dc.identifier.urihttp://hdl.handle.net/10198/24901
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMountain Research Center
dc.relationNatural colorants based on anthocyanins obtained from bioresidues
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGarcinia mangostana L.pt_PT
dc.titleFlavonoid composition and in vitro anti-proliferative activity of the hydroethanolic extracts of Garcinia mangostana L. pericarppt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleNatural colorants based on anthocyanins obtained from bioresidues
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F136370%2F2018/PT
oaire.citation.conferencePlaceBragança, Portugalpt_PT
oaire.citation.title1st Congress on Natural products application: Health, Cosmetic and Foodpt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAlbuquerque
person.familyNameDias
person.familyNameCalhelha
person.familyNameFerreira
person.familyNameBarros
person.givenNameBianca R.
person.givenNameMaria Inês
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.givenNameLillian
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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