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Cytotoxicity of portuguese propolis: the proximity of the in vitro doses for tumor and normal cell lines

2014Journal article Open access
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dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFalcão, Soraia
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorVilas-Boas, Miguel
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2014-08-14T08:49:04Z
dc.date.available2014-08-14T08:49:04Z
dc.date.issued2014
dc.description.abstractWith a complex chemical composition rich in phenolic compounds, propolis (resinous substance collected by Apis mellifera from various tree buds) exhibits a broad spectrum of biological activities. Recently, in vitro and in vivo data suggest that propolis has anticancer properties, but is the cytoxicity of propolis specific for tumor cells? To answer this question, the cytotoxicity of phenolic extracts from Portuguese propolis of different origins was evaluated using human tumor cell lines (MCF7-breast adenocarcinoma, NCI-H460-non-small cell lung carcinoma, HCT15-colon carcinoma, HeLa-cervical carcinoma, and HepG2-hepatocellular carcinoma), and non-tumor primary cells (PLP2). The studied propolis presented high cytotoxic potential for human tumor cell lines, mostly for HCT15. Nevertheless, excluding HCT15 cell line, the extracts at the GI50 obtained for tumor cell lines showed, in general, cytotoxicity for normal cells (PLP2). Propolis phenolic extracts comprise phytochemicals that should be further studied for their bioactive properties against human colon carcinoma. In the other cases, the proximity of the in vitro cytotoxic doses for tumor and normal cell lines should be confirmed by in vivo tests and may highlight the need for selection of specific compounds within the propolis extract.por
dc.description.sponsorshipFoundation for Science and Technology (FCT), Portugal, for providing the financial support to the research centers CIMO (PEst-OE/AGR/UI0690/2011) and CQ-UM (PEst-C/QUI/UI0686/2011). Ricardo C. Calhelha thanks FCT, POPH-QREN, and FSE for his Grant (SFRH/BPD/68344/2010). Thanks are also due to the National Federation of Portuguese Beekeepers for supplying propolis samples.por
dc.identifier.citationCalhelha, Ricardo C.; Falcão, Soraia; Queiroz, Maria João R.P.; Vilas-Boas, Miguel; Ferreira, Isabel C.F.R. (2014). Cytotoxicity of portuguese propolis: the proximity of the in vitro doses for tumor and normal cell lines. BioMed Research International. ISSN 2314-6141. p. 1-7por
dc.identifier.doi10.1155/2014/897361
dc.identifier.issn2314-6141
dc.identifier.urihttp://hdl.handle.net/10198/10152
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherHindawipor
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationStrategic Project - UI 686 - 2011-2012
dc.titleCytotoxicity of portuguese propolis: the proximity of the in vitro doses for tumor and normal cell linespor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleStrategic Project - UI 686 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FQUI%2FUI0686%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.titleBioMed Research Internationalpor
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameCalhelha
person.familyNameFalcão
person.familyNameVilas-Boas
person.familyNameFerreira
person.givenNameRicardo C.
person.givenNameSoraia
person.givenNameMiguel
person.givenNameIsabel C.F.R.
person.identifier711432
person.identifier1693134
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-idD41A-6BED-4CBB
person.identifier.ciencia-idA918-C6FF-81A4
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-3735-6951
person.identifier.orcid0000-0002-8665-5280
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridI-5949-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id14832459200
person.identifier.scopus-author-id6602648497
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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