Repository logo
 
Publication

Red blood cells radial dispersion in blood flowing through microchannels: the role of temperature

2016Journal article Restricted access
Simple item page
dc.contributor.authorPinho, Diana
dc.contributor.authorRodrigues, Raquel Oliveira
dc.contributor.authorFaustino, Vera
dc.contributor.authorYaginuma, Tomoko
dc.contributor.authorExposto, José
dc.contributor.authorLima, Rui A.
dc.date.accessioned2018-01-31T10:00:00Z
dc.date.accessioned2018-02-01T09:37:53Z
dc.date.available2018-01-31T10:00:00Z
dc.date.available2018-02-01T09:37:53Z
dc.date.issued2016
dc.description.abstractThe behavior of suspensions of individual blood cells, such as red blood cells (RBCs), flowing through microvessels and microfluidic systems depend strongly on the hematocrit (Hct), microvessel topology and cell properties. Although it is well known that blood rheological properties are temperature dependent, to the best of our knowledge no work has studied the role of the temperature on the RBCs dispersion. A powerful way to investigate this latter effect is through a high-speed video microscopy system, which provides detailed flow measurements of each individual RBC. Hence, the effect of temperature on the RBCs dispersion flowing through a 100 μm glass capillary was examined by means of a confocal micro-PTV system. Hundreds of labeled RBCs were tracked at moderate Hct (12%) and at four different temperatures, i.e., 25 °C, 32 °C, 37 °C and 42 °C. The results yielded an enhancement of the RBCs diffusion as the temperature increases. Hence, our findings show that RBCs radial dispersion is temperature dependent and as a result the temperature should not be ignored in future blood flow studies. We believe that this finding is important for a better understanding of blood mass transport mechanisms under both physiological and pathological conditions.en_EN
dc.description.sponsorshipThe authors acknowledge the financial support provided by PTDC/SAU-ENB/116929/2010 and EXPL/EMS-SIS/2215/2013 from FCT (Science and Technology Foundation), COMPETE, QREN and European Union (FEDER). R. O. Rodrigues, D. Pinho and V. Faustino acknowledge respectively, the PhD scholarships SFRH/BD/97658/2013, SFRH/BD/89077/2012 and SFRH/BD/99696/2014 Granted by FCT. The authors are also very grateful to Professor Takuji Ishikawa and Professor Takami Yamaguchi (Tohoku University) for supporting this research work.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationPinho, Diana; Rodrigues, Raquel O.; Faustino, Vera; Yaginuma, Tomoko; Exposto, José; Lima, Rui (2016). Red blood cells radial dispersion in blood flowing through microchannels: the role of temperature. Journal of Biomechanics. ISSN 0021-9290. 49, p. 2293-2298en_EN
dc.identifier.doi10.1016/j.jbiomech.2015.11.037en_EN
dc.identifier.issn0021-9290
dc.identifier.urihttp://hdl.handle.net/10198/15392
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMicrofluidic system for cell separation and deformation assessment based on biomimetic and acoustofluidic methods
dc.relationBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
dc.relationMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA
dc.subjectBiomicrofluidicsen_EN
dc.subjectBlood flowen_EN
dc.subjectConfocal micro-PTVen_EN
dc.subjectMicrocirculationen_EN
dc.subjectRadial dispersionen_EN
dc.subjectRed blood cellsen_EN
dc.subjectTemperatureen_EN
dc.titleRed blood cells radial dispersion in blood flowing through microchannels: the role of temperatureen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMicrofluidic system for cell separation and deformation assessment based on biomimetic and acoustofluidic methods
oaire.awardTitleBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
oaire.awardTitleMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F99696%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-ENB%2F116929%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/EXPL%2FEMS-SIS%2F2215%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F97658%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F89077%2F2012/PT
oaire.fundingStreamFARH
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamCOMPETE
oaire.fundingStreamSFRH
person.familyNamePinho
person.familyNameExposto
person.familyNameLima
person.givenNameDiana
person.givenNameJosé
person.givenNameRui A.
person.identifier.ciencia-id5214-ED0C-35E8
person.identifier.ciencia-idDA10-808F-99EA
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.orcid0000-0002-3884-6496
person.identifier.orcid0000-0003-3857-6083
person.identifier.orcid0000-0003-3428-637X
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id56619498700
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication02bf2dd9-33ed-4d87-b61d-ca39c51f8451
relation.isAuthorOfPublication66fd8128-90b1-4754-936e-2d9e9e0829ec
relation.isAuthorOfPublication7b50c499-8095-4f4f-8b1b-fa7388e4ff62
relation.isAuthorOfPublication.latestForDiscovery02bf2dd9-33ed-4d87-b61d-ca39c51f8451
relation.isProjectOfPublication6011159d-ef39-4190-8961-d1fc00e91fdc
relation.isProjectOfPublication0785b517-d2cf-4d92-b2e1-d45afee17273
relation.isProjectOfPublication7aa7bf1a-0dca-461e-90aa-9ca40cbedcb7
relation.isProjectOfPublication95f49ee8-5b1f-45de-b818-d9334a4d8d0e
relation.isProjectOfPublicationa703ea48-10f3-42ed-867e-2aae71b722e8
relation.isProjectOfPublication.latestForDiscovery6011159d-ef39-4190-8961-d1fc00e91fdc

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
23.pdf
Size:
1.96 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Plain Text
Description:
Download

Collections

ESTiG - Artigos em Revistas Indexados à WoS/Scopus