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Growth inhibitory activity of Coprinopsis atramentaria extract, phenolic acids and protected acetylated glucuronides on human tumor and non-tumor cell lines

2013Conference object Open access
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dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorMartins, Anabela
dc.contributor.authorEsteves, Ana P.
dc.contributor.authorQueiroz, Maria João R.P.
dc.date.accessioned2013-09-09T09:50:20Z
dc.date.available2013-09-09T09:50:20Z
dc.date.issued2013
dc.description.abstractMushrooms represent an important source of compounds with antitumor and immunostimulating properties. Our attention is being focused on the capacity of phenolic acids from mushrooms to miHb1t the growth of different tumor cell lines. Croprinopsis atramentaria (Bull.: Fr.) Redhead, Vilgalys & Moncalvo, is a wild edible mushroom previously characterized by us for its nutritional composition, and also showed a notable antioxidant activity; p-hydroxybenzoic (4.71 mg/100 g dry weight), p -coumaric (0.82 mg/100 g) and cinnamic ( 1.70 mg/100 g) acids were identified in its phenolic extract.PIJ·Icrcin, the growth inhibitory activity on human tumor cell lines (breast- MCF-7, non-small cell lung- NCI-H460, colon- HCT- 15, hepatocellular- HepG2 and cervical HeLa) and non-tumor porcine liver primary cell culture (PLP2), was evaluated by sulforhodamine B assay, using C. atramentaria extract, phenolic acids, cinnamic acid and their protected glucuronides (HAGP, CoAGP and CAGP; Scheme) obtained reacting phydroxybenzoic (HA), p-coumaric (CoA) and cinnamic (CA) acids, respectively, with acetobromo-a-0-glucuronic acid methyl esterpor
dc.description.sponsorshipFCT for financial support to the Portuguese NMR network and COMPETEIQRENIEU (PTDC/AGR-ALI/110062/2009, PEst-OE/AGR/UI0690/201 and PEstC/QUI/UI0686/2011)for financial support. S.A. Heleno (BD/7030412010) and R.C. Calhelha (BPD/68344/2010) also thank FCT. POP/1-QREN and FSE.por
dc.identifier.citationHeleno, Sandrina A.; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Martins, Anabela; Esteves, Ana P.; Queiroz, Maria João R.P. (2013). Growth inhibitory activity of Coprinopsis atramentaria extract, phenolic acids and protected acetylated glucuronides on human tumor and non-tumor cell lines. In XXIII Encontro Nacional da SPQ. Aveiropor
dc.identifier.urihttp://hdl.handle.net/10198/8663
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationStrategic Project - UI 686 - 2011-2012
dc.relationIMPORTANT HUMAN METABOLITES OF PHENOLIC ACIDS FROM DIET WITH WILD EDIBLE MUSHROOMS: CHEMICAL SYNTHESIS AND STUDIES OF THEIR ANTIOXIDANT AND ANTITUMOR PROPERTIES
dc.titleGrowth inhibitory activity of Coprinopsis atramentaria extract, phenolic acids and protected acetylated glucuronides on human tumor and non-tumor cell linespor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleStrategic Project - UI 686 - 2011-2012
oaire.awardTitleIMPORTANT HUMAN METABOLITES OF PHENOLIC ACIDS FROM DIET WITH WILD EDIBLE MUSHROOMS: CHEMICAL SYNTHESIS AND STUDIES OF THEIR ANTIOXIDANT AND ANTITUMOR PROPERTIES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FQUI%2FUI0686%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F70304%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.conferencePlaceAveiro, Portugalpor
oaire.citation.titleXXIII Encontro Nacional da SPQpor
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameHeleno
person.familyNameFerreira
person.familyNameCalhelha
person.familyNameMartins
person.givenNameSandrina A.
person.givenNameIsabel C.F.R.
person.givenNameRicardo C.
person.givenNameAnabela
person.identifier144781
person.identifier.ciencia-id8B18-3095-6FC9
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person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-6218-4413
person.identifier.ridL-5951-2014
person.identifier.ridE-8500-2013
person.identifier.ridJ-2172-2014
person.identifier.ridG-5488-2013
person.identifier.scopus-author-id30067731800
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id7203013518
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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