Repository logo
 
Publication

Lovage (Levisticum officinale W.D.J. Koch) roots: a source of bioactive compounds towards a circular economy

2020Journal article Open access
Simple item page
dc.contributor.authorSprea, Rafael M.
dc.contributor.authorFernandes, Ângela
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorPereira, Carla
dc.contributor.authorAlves, Maria José
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorCanan, Cristiane
dc.contributor.authorBarros, Lillian
dc.contributor.authorAmaral, Joana S.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-02-27T17:20:54Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-02-27T17:20:54Z
dc.date.issued2020
dc.description.abstractLovage (Levisticum officinale W.D.J. Koch) is an aromatic plant from the Apiaceae (Umbelliferae) family used as a condiment in several regions of Europe and also described to have medicinal properties. While the aerial parts are used as foods, the roots are generally discarded. In the past, lovage roots were used in folk medicine for their diuretic, carminative, and spasmolytic properties. Therefore, the exploitation of this undervalued part of the plant can be a source of valuable bioactive compounds for food and/or pharmaceutical industries. Thus, in this study, extracts of different polarity were prepared and studied regarding their chemical composition and bioactive properties. To the best of our knowledge, the composition in phenolic compounds and the volatile profile of the n-hexane extract are reported for the first time. A total of 24 compounds were identified by GC-MS in the n-hexane extract, evidencing a high relative abundance of phthalides. A total of eight phenolic compounds were identified in lovage root extracts (decoction and hydroethanolic extract), with vanillic acid being the major compound. Regarding antioxidant activity, also reported for the first time, decoction and hydroethanolic extract exhibited a high antioxidant capacity in thiobarbituric acid reactive substances (TBARS) (179 ± 11 μg/mL) and in oxidative hemolysis (OxHLIA) assays (510 ± 6 μg/mL), respectively. n-Hexane extract showed relevant anti-proliferative activity against all tumor cell lines tested (GI50, 48-69 μg/mL), despite inhibiting also the growth of a non-tumoral hepatocyte cell line, however, presenting a significantly higher GI50 value (147 μg/mL). This study revealed that lovage root, an agri-food residue, can be a source of valuable bioactive compounds also presenting biological properties that deserve being explored, which could lead to a circular economy for food and/or the pharmaceutical industry.en_EN
dc.description.sponsorshipNational funding by Foundation for Science and Technology, P.I., through the institutional scientific employment program-contract for A. Fernandes, L. Barros, and R. C. Calhelha contracts and C. Pereira contract though the celebration of program-contract foreseen in No. 4, 5, and 6 of article 23º of Decree-Law No. 57/2016, of 29th August, amended by Law No. 57/2017, of 19th July. This work was also funded by FEDER-Interreg España-Portugal programme through the project 0377_Iberphenol_6_E and TRANSCoLAB 0612_TRANS_CO_LAB_2_P. The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2019).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationSpréa, Rafael Mascoloti; Fernandes, Ângela; Finimundy, Tiane C.; Pereira, Carla; Alves, Maria José; Calhelha, Ricardo C.; Canan, Cristiane; Barros, Lillian; Amaral, Joana S.; Ferreira, Isabel C.F.R. (2020). Lovage (Levisticum officinale W.D.J. Koch) roots: A source of bioactive compounds towards a circular economy. Resources. ISSN 2079-9276. 9:9, p. 1-16en_EN
dc.identifier.doi10.3390/RESOURCES9070081en_EN
dc.identifier.urihttp://hdl.handle.net/10198/23404
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectAgri-food wasteen_EN
dc.subjectBioactivityen_EN
dc.subjectCircular economyen_EN
dc.subjectLevisticum officinale rootsen_EN
dc.subjectPhenolic compoundsen_EN
dc.subjectPhthalidesen_EN
dc.titleLovage (Levisticum officinale W.D.J. Koch) roots: a source of bioactive compounds towards a circular economyen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameSprea
person.familyNameFernandes
person.familyNameFinimundy
person.familyNamePereira
person.familyNameAlves
person.familyNameCalhelha
person.familyNameBarros
person.familyNameAmaral
person.familyNameFerreira
person.givenNameRafael M.
person.givenNameÂngela
person.givenNameTiane C.
person.givenNameCarla
person.givenNameMaria José
person.givenNameRicardo C.
person.givenNameLillian
person.givenNameJoana S.
person.givenNameIsabel C.F.R.
person.identifier1415151
person.identifier469085
person.identifier144781
person.identifier.ciencia-id001F-273E-3A67
person.identifier.ciencia-id2015-0434-AE7C
person.identifier.ciencia-id2F18-67B1-776A
person.identifier.ciencia-idEF10-2739-2B70
person.identifier.ciencia-idD618-B3A9-D312
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id5319-7DE8-BEDA
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-0157-9873
person.identifier.orcid0000-0003-3516-0795
person.identifier.orcid0000-0003-0093-771X
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-3648-7303
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridK-1629-2016
person.identifier.ridM-6624-2016
person.identifier.ridJ-2172-2014
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id55627876424
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication7779265b-4054-4822-9a2a-03b1482c81e0
relation.isAuthorOfPublication6233e657-3885-40a3-885e-0d51cf4dbaad
relation.isAuthorOfPublication4f8767d4-4e62-4550-9b35-740cb2f672da
relation.isAuthorOfPublicatione07a8e12-52bb-47c5-bae7-41a5f648213b
relation.isAuthorOfPublication7850f8c2-8834-4d5a-b4a7-df482abd76d3
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication42be2cf4-adc4-4e7f-ac60-7aab515b38cd
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
66.pdf
Size:
1.11 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Plain Text
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus