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Leccinum vulpinum Watling induces DNA damage, decreases cell proliferation and induces apoptosis on the human MCF-7 breast cancer cell line

2016Journal article Open access
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dc.contributor.authorReis, Filipa S.
dc.contributor.authorSousa, Diana
dc.contributor.authorBarros, Lillian
dc.contributor.authorMartins, Anabela
dc.contributor.authorMorales, Patricia
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorVasconcelos, M. Helena
dc.date.accessioned2016-10-03T09:16:33Z
dc.date.available2016-10-03T09:16:33Z
dc.date.issued2016
dc.description.abstractThe current work aimed to study the antitumour activity of a phenolic extract of the edible mushroom Leccinum vulpinum Watling, rich essentially in hydroxybenzoic acids. In a first approach, the mushroom extract was tested against cancer cell growth by using four human tumour cell lines. Given the positive results obtained in these initial screening experiments and the evidence of some studies for an inverse relationship between mushroom consumption and breast cancer risk, a detailed study of the bioactivity of the extract was carried out on MCF-7 cells. Once the selected cell line to precede the work was the breast adenocarcinoma cell line, the human breast non-malignant cell line MCF-10A was used as control. Overall, the extract decreased cellular proliferation and induced apoptosis. Furthermore, the results also suggest that the extract causes cellular DNA damage. Data obtained highlight the potential of mushrooms as a source of biologically active compounds, particularly with antitumour activity.pt_PT
dc.description.sponsorshipIPATIMUP integrates the i3S Research Unit, which is partially supported by FCT, the Portuguese Foundation for Science and Technology. This work is funded by FEDER funds through the Operational Programme for Competitiveness Factors-COMPETE and National Funds through the FCT-Foundation for Science and Technology, under the projects "PEst-C/SAU/LA0003/2013", NORTE-07-0162-FEDER-00018 - Contributos para o reforço da capacidade do IPATIMUP enquanto actor do sistema regional de inovação" and NORTE-07-0162-FEDER-000067 - Reforço e consolidação da capacidade infraestrutural do IPATIMUP para o sistema regional de inovação", both supported by Programa Operacional Regional do Norte (ON.2 – O Novo Norte), through FEDER funds under the Quadro de Referência Estratégico Nacional (QREN). Authors also thank COMPETE/QREN/EU for the financial support to CIMO (strategic project PEst-OE/AGR/UI0690/2014) and L. Barros. The authors also thank QREN for the grant of F.S. Reis (NORTE-07-0124-FEDER-000023) and FCT for the grant of D. Sousa (SFRH/BD/98054/2013), Dr. Maria João Sousa for helping in the harvesting of samples.pt_PT
dc.identifier.citationReis, Filipa S.; Sousa, Diana; Barros, Lillian; Martins, Anabela; Morales, Patricia; Ferreira, Isabel C.F.R.; Vasconcelos, M. Helena (2016). Leccinum vulpinum Watling induces DNA damage, decreases cell proliferation and induces apoptosis on the human MCF-7 breast cancer cell line. Food and Chemical Toxicology. ISSN 0278-6915. 90, p. 45–54pt_PT
dc.identifier.doi10.1016/j.fct.2016.02.005pt_PT
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/10198/13351
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationUnderstanding the interactions between P-glycoprotein and microRNAs in the transfer of drug resistance by extracellular vesicles
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMushroomspt_PT
dc.subjectPhenolic extractpt_PT
dc.subjectBioactive compoundspt_PT
dc.subjectAntitumour potentialpt_PT
dc.subjectApoptosispt_PT
dc.subjectDNA damagept_PT
dc.titleLeccinum vulpinum Watling induces DNA damage, decreases cell proliferation and induces apoptosis on the human MCF-7 breast cancer cell linept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleUnderstanding the interactions between P-glycoprotein and microRNAs in the transfer of drug resistance by extracellular vesicles
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FSAU%2FLA0003%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F98054%2F2013/PT
oaire.citation.endPage54pt_PT
oaire.citation.startPage45pt_PT
oaire.citation.titleFood and Chemical Toxicologypt_PT
oaire.citation.volume90pt_PT
oaire.fundingStreamCOMPETE
oaire.fundingStream5876
person.familyNameReis
person.familyNameBarros
person.familyNameMartins
person.familyNameFerreira
person.givenNameFilipa S.
person.givenNameLillian
person.givenNameAnabela
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id391F-AFE1-64C7
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id7B18-A810-6B93
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9159-0530
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-6218-4413
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridI-2093-2013
person.identifier.ridJ-3600-2013
person.identifier.ridG-5488-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36982144400
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id7203013518
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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