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Satureja montana L. And origanum majorana L. decoctions: Antimicrobial activity, mode of action and phenolic characterization

2020Journal article Open access
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dc.contributor.authorGomes, Fernanda
dc.contributor.authorDias, Maria Inês
dc.contributor.authorLima, Ângela
dc.contributor.authorBarros, Lillian
dc.contributor.authorRodrigues, Maria Elisa
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorHenriques, Mariana
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-02-27T17:37:48Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-02-27T17:37:48Z
dc.date.issued2020
dc.description.abstractMedicinal and aromatic plants are known to have a wide range of uses and health benefits, and should be exploited for their bioactivity. Here we evaluated the antimicrobial activity of decoctions of Satureja montana L. and Origanum majorana L. against Gram-positive and Gram-negative bacteria and Candida spp. as well as their mechanism of action and phenolic characterization. The Satureja montana and Origanum majorana extracts were effective against a broad set of species, including the Gram-positive Staphylococcus aureus, Enterococcus faecalis, and Streptococcus dysgalactiae and the Gram-negative Klebsiella pneumoniae and Pseudomonas aeruginosa. Both extracts were found to have rosmarinic acid as the main phenolic compound and to exert their antimicrobial activity at the level of the cell membrane. Membrane perturbations by the extracts impaired cell membrane integrity only a few hours after exposure. This study confirms the bioactive potential of Satureja montana and Origanum majorana decoctions, and supports the development of novel formulations with wide antimicrobial properties based on these medicinal and aromatic herbs.en_EN
dc.description.sponsorshipThis study was supported by the Portuguese Foundation for Science and Technology (FCT) (grant number SFRH/BPD/84488/2012 and SFRH/BPD/93078/2013) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020—Programa Operacional Regional do Norte. The authors are also grateful to FCT for financial support by national funds FCT/MCTES to CIMO (UIDB/00690/2020), and through the institutional scientific employment program-contract for Maria Inês Dias and Lillian Barros. FEDER-Interreg España-Portugal through project 0377_Iberphenol_6_E and TRANSCoLAB 0612_TRANS_CO_LAB_2_P.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationGomes, Fernanda; Dias, Maria Inês; Lima, Ângela; Barros, Lillian; Rodrigues, Maria Elisa; Ferreira, Isabel C.F.R.; Henriques, Mariana (2020). Satureja montana L. And origanum majorana L. decoctions: Antimicrobial activity, mode of action and phenolic characterization. Antibiotics. ISSN 2079-6382. 9:6, p. 1-12en_EN
dc.identifier.doi10.3390/antibiotics9060294en_EN
dc.identifier.urihttp://hdl.handle.net/10198/23411
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.subjectAntimicrobial activityen_EN
dc.subjectDecoctionen_EN
dc.subjectMechanism of actionen_EN
dc.subjectOriganum majoranaen_EN
dc.subjectPhenolic characterizationen_EN
dc.subjectSatureja montanaen_EN
dc.titleSatureja montana L. And origanum majorana L. decoctions: Antimicrobial activity, mode of action and phenolic characterizationen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameDias
person.familyNameBarros
person.familyNameFerreira
person.givenNameMaria Inês
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication7ca8432b-e7f4-4116-a56e-9eba0d4403bd
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isProjectOfPublication29718e93-4989-42bb-bcbc-4daff3870b25
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