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Arylxanthones with anti-inflammator potential in cellular systems

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dc.contributor.authorSantos, Clementina M.M.
dc.contributor.authorRibeiro, Daniela
dc.contributor.authorSilva, Artur
dc.contributor.authorFernandes, Eduarda
dc.date.accessioned2017-11-09T12:20:18Z
dc.date.available2017-11-09T12:20:18Z
dc.date.issued2016
dc.description.abstractXanthones are a family of naturally-occurring oxygenated heterocyclic compounds. A wide range of natural and synthetic analogues are known to possess diverse biological activities including antifungal, antimalarial, antioxidant and antitumor, among others [1]. There are only a few publications related to arylxanthones [2], most of them focused on arylxanthones synthetic strategies and their biomedical potential, mainly highlighting them as effective scavengers of reactive oxygen species (ROS) and reactive nitrogen species (RNS) [3,4]. As far as we know, the anti-inflammatory potential of xanthones bearing an aryl group has not been studied so far. With this idea in mind, our purpose was to evaluate the putative anti-inflammatory effects of several arylxanthones bearing hydroxyl groups in certain positions of their main core, namely through their ability to inhibit 5-lipoxygenase (5-LOX) and cyclooxygenase 1 (COX-1) and 2 (COX-2), both enzymes involved in the arachidonic acid metabolism [5,6]. Preliminary results showed that some of the studied arylxanthones were able to prevent leukotriene B4 production in human neutrophils, the xanthone with a catechol group at position 2 being the most active one. The inhibition of prostaglandin E2 production was assessed in human whole blood and the majority of the tested compounds were able to inhibit COX-1 while being completely ineffective in COX-2.pt_PT
dc.description.sponsorshipSincere thanks are expressed to Faculdade de Farmácia da Universidade do Porto, Universidade de Aveiro, Instituto Politécnico de Bragança, Fundação para a Ciência e a Tecnologia (FCT, Portugal), European Union, FEDER, PT 2020, QREN, and COMPETE funding UCIBIO, REQUIMTE [(PT2020 UID/MULTI/04378/2013 - POCI/01/0145/FEDER/007728), (NORTE-01-0145-FEDER-000024), and (PTDC/QEQ-QAN/1742/2014 – POCI- 01-0145-FEDER-016530)] and QOPNA (FCT UID/QUI/00062/2013) Research Units.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, Clementina M.M.; Ribeiro, Daniela; Silva, Artur; Fernandes, Eduarda (2016). Arylxanthones with anti-inflammator potential in cellular systems. In XXII Encontro Luso-Galego de Química. Bragança: Sociedade Portuguesa de Química. ISBN 978-989-8124-17-3pt_PT
dc.identifier.isbn978-989-8124-17-3
dc.identifier.urihttp://hdl.handle.net/10198/14611
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCarotenoid oxidation by reactive oxygen and nitrogen species: chemical analysis and biological activity
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.titleArylxanthones with anti-inflammator potential in cellular systemspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleCarotenoid oxidation by reactive oxygen and nitrogen species: chemical analysis and biological activity
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04378%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FQEQ-QAN%2F1742%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00062%2F2013/PT
oaire.citation.conferencePlaceBragança, Portugalpt_PT
oaire.citation.titleXXII Encontro Luso-Galego de Químicapt_PT
oaire.fundingStream5876
oaire.fundingStream9471 - RIDTI
oaire.fundingStream5876
person.familyNameSantos
person.givenNameClementina M.M.
person.identifier.ciencia-id9018-DB9C-C590
person.identifier.orcid0000-0003-4380-7990
person.identifier.scopus-author-id7201458663
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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relation.isAuthorOfPublication.latestForDiscovery64f662b6-775d-4ea0-bfd7-f527af0ac1a0
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