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Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage

2023Journal article Open access
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dc.contributor.authorOliveira, Daniela
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorCustódio, Luísa
dc.contributor.authorOliveira, Rui P.
dc.date.accessioned2023-03-21T11:28:42Z
dc.date.available2023-03-21T11:28:42Z
dc.date.issued2023
dc.description.abstractLong-term exposure to dietary xenobiotics can induce oxidative stress in the gastrointestinal tract, possibly causing DNA damage and contributing to the initiation of carcinogenesis. Halophytes are exposed to constant abiotic stresses, which are believed to promote the accumulation of antioxidant metabolites like polyphenols. The aim of this study was to evaluate the antioxidant and antigenotoxic properties of the ethanol extract of the aerial part of the halophyte Polygonum maritimum L. (PME), which can represent a dietary source of bioactive compounds with potential to attenuate oxidative stress-related damage. The PME exhibited a high antioxidant potential, revealed by the in vitro capacity to scavenge the free radical DPPH (IC50 = 2.29 +/- 0.10 mu g/mL) and the improved viability of the yeast Saccharomyces cerevisiae under oxidative stress (p < 0.001, 10 min). An antigenotoxic effect of PME against H2O2-induced oxidative stress was found in S. cerevisiae (p < 0.05) with the dominant deletion assay. In vitro colorimetric assays and LC-DAD-ESI/MSn analysis showed that PME is a polyphenol-rich extract composed of catechin, (epi)catechin dimer and trimers, quercetin and myricetin glycosides. Hence, P. maritimum is a source of antioxidant and antigenotoxic metabolites for application in industries that develop products to provide health benefits.pt_PT
dc.description.sponsorshipD. Oliveira acknowledges the financial support provided by national funds through FCT – Portuguese Foundation for Science and Technology (PD/BD/135329/2017), under the PhD AgriChains (PD/00122/2012) and from the European Social Funds and the Regional Operational Programme Norte 2020. This study was also supported by the research units CITAB (UIDB/04033/2020) and CBMA (UIDB/04050/2020). L. Custódio acknowledges FCT for the UIDB/04326/2020 and PTDC/BAA-AGR/1391/2020 projects, and Scientific Employment Stimulus (CEECIND/00425/2017). The authors are also grateful to FCT (Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020); National funding by FCT, P.I., through the individual scientific employment program-contract for M.I. Dias and L. Barros contracts.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira, Daniela; Dias, Maria Inês; Barros, Lillian; Custódio, Luísa; Oliveira, Rui P. (2023). Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage. Scientific Reports. ISSN 2045-2322. 13:1, p. 1-10pt_PT
dc.identifier.doi10.1038/s41598-022-20402-5
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10198/27894
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Portfolio
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIn-vitropt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectDietary polyphenolspt_PT
dc.subjectPhenolic-compoundspt_PT
dc.subjectFao cellspt_PT
dc.subjectFlavonoids
dc.subjectProducts
dc.subjectExtracts
dc.subjectProtect
dc.titleAntigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damagept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleScientific Reportspt_PT
person.familyNameDias
person.familyNameBarros
person.givenNameMaria Inês
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7ca8432b-e7f4-4116-a56e-9eba0d4403bd
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery7ca8432b-e7f4-4116-a56e-9eba0d4403bd

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