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Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetry

2013Journal article Open access
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dc.contributor.authorSantos, Clementina M.M.
dc.contributor.authorGarcia, Beatriz
dc.contributor.authorSilva, Artur
dc.contributor.authorSantus, René
dc.contributor.authorMorlière, Patrice
dc.contributor.authorFernandes, Eduarda
dc.date.accessioned2014-03-11T11:14:00Z
dc.date.available2014-03-11T11:14:00Z
dc.date.issued2013
dc.description.abstractThe present study reports the electrochemical behavior of several phenolic and catecholic-substituted 2,3-diarylxanthones on a glassy carbon electrode, challenged by cyclic voltammetry at different pH values (4.0, 7.4, and 11.0). Higher pH values required lower anodic and cathodic peak voltages. The oxidation of catecholic groups occurred at lower peak potentials in a reversible and pH dependent manner. Anodic peak potentials appeared at higher pH values and were attributed to the electrochemically irreversible oxidation of the phenolic groups. The number and position of hydroxyl substituents were the determinants for the electrochemical behavior and found to correlate with the scavenging activity for reactive oxygen (ROS) and nitrogen species (RNS). A xanthone with two catechol units presented the lowest anodic potential voltage (Epa = 0.15 V) and proved to be the most effective ROS and RNS scavenger.por
dc.description.sponsorshipFaculdade de Farmácia da Universidade do Porto, Universidade de Aveiro, Fundação para a Ciência e a Tecnologia (Portugal) and FEDER for funding the Organic Chemistry Research Unit (project PEst-C/QUI/UI0062/2011) and also to the Portuguese National NMR Network (RNRMN).por
dc.identifier.citationSantos, Clementina M.M.; Garcia, Beatriz; Silva, Artur M. S.; Santus, Rene; Morliere, Patrice; Fernandes, Eduarda (2013). Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetry. Tetrahedron Letters. ISSN 0040-4039. 54:1, p. 85-90.por
dc.identifier.doi10.1016/j.tetlet.2012.10.103
dc.identifier.urihttp://hdl.handle.net/10198/9350
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectXanthonespor
dc.subjectCyclic voltammetrypor
dc.subjectScavenging activity for ROS and RNSpor
dc.subjectCatecholpor
dc.subjectGlassy carbonpor
dc.titleElectrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetrypor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceElsevierpor
oaire.citation.endPage90por
oaire.citation.startPage85por
oaire.citation.titleTetrahedron Letterspor
oaire.citation.volume54por
person.familyNameSantos
person.givenNameClementina M.M.
person.identifier.ciencia-id9018-DB9C-C590
person.identifier.orcid0000-0003-4380-7990
person.identifier.scopus-author-id7201458663
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication64f662b6-775d-4ea0-bfd7-f527af0ac1a0
relation.isAuthorOfPublication.latestForDiscovery64f662b6-775d-4ea0-bfd7-f527af0ac1a0

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