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Valorization of Solanum melongena L. crop by-products: Phenolic composition and in vitro antioxidant, antidiabetic, anti-inflammatory, cytotoxic, and antimicrobial properties

2025Journal article Open access
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datacite.subject.fosCiências Agrárias::Agricultura, Silvicultura e Pescas
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg15:Proteger a Vida Terrestre
dc.contributor.authorAñibarro-Ortega, Mikel
dc.contributor.authorDias, Maria Inês
dc.contributor.authorPetrović, Jovana
dc.contributor.authorNúñez, Sonia
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorCosta, Eduardo M.
dc.contributor.authorMachado, M.
dc.contributor.authorPintado, Manuela
dc.contributor.authorSoković, Marina
dc.contributor.authorLópez, Víctor
dc.contributor.authorBarros, Lillian
dc.contributor.authorPinela, José
dc.date.accessioned2025-05-29T13:04:42Z
dc.date.available2025-05-29T13:04:42Z
dc.date.issued2025
dc.description.abstractThis study explored the valorization of post-harvest eggplant aerial parts as a sustainable source of value-added ingredients by investigating their phenolic composition and in vitro bioactive properties. HPLC-DAD-ESI/MSn analysis identified chlorogenic acid derivatives as the predominant phenolic compounds (53 % of the phenolic fraction), followed by O-glycosylated kaempferol and quercetin. The extract displayed antioxidant activity in physiologically relevant cell-based assays and significant α-glucosidase inhibitory capacity that far exceeded that of the standard drug acarbose. It also inhibited the formation of advanced glycation end-products (AGEs), suggesting its potential to mitigate diabetes-related complications. Furthermore, the extract showed a modest pancreatic lipase inhibitory effect and capacity to suppress interleukin 6 production. Selective cytotoxicity against human gastric and colon adenocarcinoma cell lines and strong antimicrobial activity against foodborne pathogens were observed. Given the growing demand for natural alternatives to synthetic drugs, these findings position eggplant crop biomass as a promising, sustainable source of active compounds with potential applications in food, nutraceutical, and pharmaceutical formulations for managing type 2 diabetes and other oxidative stress-mediated conditions. This study not only contributes to the valorization of agricultural waste but also expands the research on by-products of Solanaceae crops, offering a pathway for sustainable resource utilization.eng
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020), SusTEC (LA/P/0007/2021) and CBQF (UIDB/50016/2020). National funding by FCT, through the individual research grant (DOI: 10.54499/2020.06297.BD) of M. Ãnibarro-Ortega and the scientific employment program-contract with M.I. Dias (DOI: 10.54499/CEE-CINST/00016/2018/CP1505/CT0004), R.C. Calhelha (CEECINST), E.M Costa (DOI: 10.54499/2022.07206.CEECIND/CP1745/CT0003), L. Barros (DOI: 10.54499/CEECINST/00107/2021/CP2793/CT0002) and J. Pinela (DOI: 10.54499/CEECIND/01011/2018/CP1578/CT0002). J. Petrovíc and M. Sokovíc are grateful to the Serbian Ministry of Education, Science and Technological Development (contract nos. 451–03–9/2021–14/200007). V. López is grateful to the San Jorge University for the financial support through Proyecto Interno 20–21 (ID 2122028) and to the Government of Aragon for financial support of the Phyto-Pharm group (ref. B44_20D)
dc.identifier.citationAñibarro-Ortega, Mikel; Dias, Maria Inês; Petrović, Jovana; Núñez, Sonia; Calhelha, Ricardo C.; Costa, Eduardo M.; Machado, M.; Pintado, Manuela; Soković, Marina; López, Víctor; Barros, Lillian; Pinela, José (2025). Valorization of Solanum melongena L. crop by-products: Phenolic composition and in vitro antioxidant, antidiabetic, anti-inflammatory, cytotoxic, and antimicrobial properties. Process Biochemistry. ISSN 153, p. 315- 324
dc.identifier.doi10.1016/j.procbio.2025.04.002
dc.identifier.issn1359-5113
dc.identifier.urihttp://hdl.handle.net/10198/34502
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationCentre of Biotechnology and Fine Chemistry
dc.relation.ispartofProcess Biochemistry
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEggplant crop by-products
dc.subjectChlorogenic acid
dc.subjectα-glucosidase inhibition
dc.subjectAntioxidant activity
dc.subjectCytotoxic activity
dc.subjectFunctional food ingredient
dc.titleValorization of Solanum melongena L. crop by-products: Phenolic composition and in vitro antioxidant, antidiabetic, anti-inflammatory, cytotoxic, and antimicrobial propertieseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleCentre of Biotechnology and Fine Chemistry
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50016%2F2020/PT
oaire.citation.endPage324
oaire.citation.startPage315
oaire.citation.titleProcess Biochemistry
oaire.citation.volume153
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAñibarro-Ortega
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person.familyNamePinela
person.givenNameMikel
person.givenNameMaria Inês
person.givenNameRicardo C.
person.givenNameLillian
person.givenNameJosé
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person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-7523-1637
person.identifier.ridM-8242-2013
person.identifier.ridJ-2172-2014
person.identifier.ridJ-3600-2013
person.identifier.ridB-4466-2014
person.identifier.scopus-author-id54388787000
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person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id54392272800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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