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A comparative study of bioactive properties of wild and commercial Achillea millefolium L.

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dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorAlves, Rita C.
dc.contributor.authorOliveira, Beatriz
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2014-03-11T17:57:29Z
dc.date.available2014-03-11T17:57:29Z
dc.date.issued2013
dc.description.abstractAchillea millefolium L., commonly known as yarrow, is a medicinal plant with high bioactive value. Its infusion, decoction and alcoholic extract are widely used in Europe to treat digestive and intestinal problems, but also due to their antitumor, antimicrobial, anti-inflammatory and antioxidant properties [1]. In the present work, methanolic extract, infusion and decoction of wild and commercial yarrow were studied for their antioxidant properties and antitumor potential, evaluated by free radicals scavenging activity, reducing power and lipid peroxidation inhibition and by estimation of the growth inhibitory activity in human tumor cell lines, respectively. Overall, cultivated yarrow showed the highest antioxidant activity, presenting the lowest EC50 values. Decoctions of both samples revealed the highest DPPH scavenging activity (0.25 and 0.20 mg/ml, respectively), 13-carotene bleaching inhibition {0.18 and 0.22 mg/ml) and TBARS inhibition (0.04 and 0.08 mg/ml), while infusions presented the highest reducing power (0.12 and 0.13 mg/ml). The samples showed a higher lipid peroxidation inhibition, but a lower DPPH scavenging activity than methanolic extract of A. millefolium from Turkey (892.67 and 45.60 11g/ml, respectively) [2]. The infusion of wild yarrow showed the highest potential against breast (MCF-7; 8 150=17.04 1-Jg/ml) and hepatocellular (HepG2; 37.60 1-Jg/ml) carcinoma cell lines, while the methanolic extract of commercial yarrow was most potent against non-small cell lung (NCI H460; 26.64 IJg/ml), colon (HCT-15, 13.90 1-Jg/ml) and cervical (Hela, 19.68 IJg/ml) carcinoma cell lines. The results obtained with the decoction and infusion of cultivated yarrow against MCF-7 line are consistent with the ones reported with ethanolic extract of A. millefolium from Iran (8150=64 .078 1-Jg/ml) [3].This is a groundbreaking study on the comparison of different extracts of A. millefolium, showing that medicinal plants can be used not only in traditional medicine but also as a source of bioactive products, namely antioxidants and antitumorals.por
dc.description.sponsorshipFoundation for Science and Technology (FCT, Portugal) for financial support to the research centre CIMO (PEst-OE/AGR/UI0690/2011 ) and REQUIMTE (PEst-C/EQB/LA0006/2011 ). M.l. Dias, L. Barros and R.C. Alves also thank to FCT, POPH-OREN and FSE for their grants (SFRH/BD/84485/2012, SFRH/BPD/4609/2008 and SFRH/BPD/68883/201 0, respectively).por
dc.identifier.citationDias, Maria Inês; Barros, Lillian; Carvalho, Ana Maria; Alves, Rita C.; Oliveira, M. Beatriz P.P.; Ferreira, Isabel C.F.R. (2013). A comparative study of bioactive properties of wild and commercial Achillea millefolium L. In 1st Symposium on Medicinal Chemistry. Braga: University of Minhopor
dc.identifier.urihttp://hdl.handle.net/10198/9371
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherUniversidade do Minhopor
dc.relationSFRH/BPD/4609/2008
dc.relationIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
dc.relationALERGÉNIOS ALIMENTARES: DESENVOLVIMENTO DE IMUNO-BIOSSENSORES ELECTROQUÍMICOS PARA SUA DETECÇÃO
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationStrategic Project - LA 6 - 2011-2012
dc.titleA comparative study of bioactive properties of wild and commercial Achillea millefolium L.por
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
oaire.awardTitleALERGÉNIOS ALIMENTARES: DESENVOLVIMENTO DE IMUNO-BIOSSENSORES ELECTROQUÍMICOS PARA SUA DETECÇÃO
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleStrategic Project - LA 6 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F84485%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F68883%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FEQB%2FLA0006%2F2011/PT
oaire.citation.conferencePlaceBraga, Portugalpor
oaire.citation.title1st Symposium on Medicinal Chemistry of University of Minhopor
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6820 - DCRRNI ID
person.familyNameDias
person.familyNameBarros
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameMaria Inês
person.givenNameLillian
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifierID G-7399-2011
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person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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