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Evaluation of Arenaria montana L. hydroethanolic extract as a chemopreventive food ingredient: A case study focusing a dairy product (yogurt)

dc.contributor.authorOliveira, Franciely dos Santos de
dc.contributor.authorRibeiro, Andreia
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorDemczuk Junior, Bogdan
dc.contributor.authorAbreu, Rui M.V.
dc.contributor.authorBarreiro, M.F.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-01-29T10:39:41Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-01-29T10:39:41Z
dc.date.issued2017
dc.description.abstractNatural ingredients are valuable options to be exploited in the design of innovative food formulations with health benefits. Therefore, it was evaluated the potential use of Arenaria montana L. hydroethanolic extract (rich in apigenin derivatives) as a chemopreventive agent in functional foods. Apigenin is recognized as inhibiting VEGFR-2, which is the key receptor involved in angiogenesis. The obtained extract was also able to inhibit the VEGFR-2 phosphorylation through an enzymatic assay (IC 50 = ~63 µg/mL). Thereafter, free and microencapsulated forms were incorporated in yogurt. The obtained products maintained the nutritional value along the tested 3 days of storage, as also free sugars and fatty acids profiles, in comparison with the control samples. Nevertheless, the VEGFR-2 phosphorylation inhibition was not exhibited as intended. Even this behavior for the microencapsulated forms can be attributed to the protecting effect of the alginate matrix, further studies are required in order to better understand the shown performance.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER for CIMO (UID/AGR/00690/2013) financial support. To POCI-01-0145-FEDER-006984 (LA LSRE-LCM) funded by ERDF through POCI-COMPETE2020 and FCT. To NORTE-01-0145-FEDER-000006, funded by NORTE 2020, under PT2020 through ERDF. L. Barros, R.C. Calhelha and J.C.M. Barreira acknowledge the FCT for their post-doctoral grants (SFRH/BPD/107855/2015, SFRH/BPD/68344/2010 and SFRH/BPD/72802/2010, respectively). The authors also thank Ana Maria Carvalho for providing Arenaria montana L. samples.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira, Franciely S.; Ribeiro, Andreia; Barros, Lillian; Calhelha, Ricardo C.; Barreira, João C.M.; Junior, Bogdan D.; Abreu, Rui M.V.; Barreiro, M.F.; Ferreira, Isabel C.F.R. (2017). Evaluation of Arenaria montana L. hydroethanolic extract as a chemopreventive food ingredient: A case study focusing a dairy product (yogurt). Journal of Functional Foods. ISSN 1756-4646. 38, Part A, p. 214-220
dc.identifier.doi10.1016/j.jff.2017.09.027pt_PT
dc.identifier.issn1756-4646
dc.identifier.urihttp://hdl.handle.net/10198/15078
dc.language.isoeng
dc.peerreviewedyespt_PT
dc.relationProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
dc.relationBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
dc.titleEvaluation of Arenaria montana L. hydroethanolic extract as a chemopreventive food ingredient: A case study focusing a dairy product (yogurt)en_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
oaire.awardTitleBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F107855%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72802%2F2010/PT
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameBarros
person.familyNameCalhelha
person.familyNameBarreira
person.familyNameAbreu
person.familyNameBarreiro
person.familyNameFerreira
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameJoão C.M.
person.givenNameRui M.V.
person.givenNameFilomena
person.givenNameIsabel C.F.R.
person.identifier469085
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person.identifier.ciencia-id9616-35CB-D001
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person.identifier.orcid0000-0002-7745-8015
person.identifier.orcid0000-0002-6844-333X
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person.identifier.ridJ-3600-2013
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person.identifier.ridD-8269-2013
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticlept_PT
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