Publication
Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch Absorption
| datacite.subject.fos | Ciências Agrárias::Agricultura, Silvicultura e Pescas | |
| datacite.subject.sdg | 15:Proteger a Vida Terrestre | |
| dc.contributor.author | Polo, Ana Caroline | |
| dc.contributor.author | Uber, Thaís Marques | |
| dc.contributor.author | Souza, Gustavo Henrique | |
| dc.contributor.author | Corrêa, Rúbia C.G. | |
| dc.contributor.author | Santos Filho, José Rivaldo dos | |
| dc.contributor.author | Sá-Nakanishi, Anacharis Babeto de | |
| dc.contributor.author | Seixas, Flávio Augusto Vicente | |
| dc.contributor.author | Bracht, Adelar | |
| dc.contributor.author | Peralta, Rosane Marina | |
| dc.date.accessioned | 2025-05-30T08:20:49Z | |
| dc.date.available | 2025-05-30T08:20:49Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Jatobá (Hymenaea courbaril) is a native tree abundant in Brazil. The fruit coat is an industrial by-product of jatobá flour processing, typically discarded. Presently, within the circular bioeconomy concept, there are efforts underway that aim at finding economically viable applications for the bio-residues of jatobá. Within this context, the present work attempts to find possible applications for the jatobá coat in glycemic control through inhibition of α-amylase activity. Aqueous and hydroethanolic extracts were used. In vitro experiments included detailed kinetic studies with an α-amylase catalyzed reaction. Starch absorption in vivo was assessed by means of a starch tolerance test in mice. Both extracts inhibited α-amylase. The IC50 values for the aqueous and hydroalcoholic extracts were 81.98 ± 3.53 µg/mL and 51.06 ± 0.42 µg/mL, respectively. The inhibition was of the non-competitive type. Both extracts reduced hyperglycemia caused by starch administration in mice, the aqueous extract being effective over a larger dose range. This action can be attributed to the α-amylase inhibition. In silico studies suggested that procyanidin dimers, taxifolin 7-O-rhamnoside, and quercetin 7-rhamnoside contribute, but several other not-yet-identified substances may be involved. The findings suggest that aqueous and hydroalcoholic extracts from jatobá coat warrant further investigations as potential modulators of glycemia following starch ingestion. | eng |
| dc.description.sponsorship | This study was funded by grants from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq 404589/2023-5) and Fundação Araucária (FA 160/2022), Brazil. | |
| dc.identifier.citation | Polo, Ana Caroline; Uber, Thaís Marques; Souza, Gustavo Henrique; Corrêa, Rúbia C.G.; Filho, José Rivaldo dos Santos; Sá-Nakanishi, Anacharis Babeto de; Seixas, Flávio Augusto Vicente; Bracht, Adelar; Peralta, Rosane Marina (2025). Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch Absorption. Plant Diversity and Evolution. ISSN 2223-7747. 14:7, p. 1-19 | |
| dc.identifier.doi | 10.3390/plants14071133 | |
| dc.identifier.issn | 2223-7747 | |
| dc.identifier.uri | http://hdl.handle.net/10198/34518 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.ispartof | Plants | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Diabetes | |
| dc.subject | α-amylase inhibition | |
| dc.subject | Starch absorption | |
| dc.subject | Glycemia | |
| dc.subject | Tannins | |
| dc.title | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch Absorption | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 19 | |
| oaire.citation.issue | 7 | |
| oaire.citation.startPage | 1 | |
| oaire.citation.title | Plants | |
| oaire.citation.volume | 14 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Corrêa | |
| person.givenName | Rúbia C.G. | |
| person.identifier.ciencia-id | 6C1F-2818-CBB5 | |
| person.identifier.orcid | 0000-0003-0269-4344 | |
| person.identifier.scopus-author-id | 37661286600 | |
| relation.isAuthorOfPublication | 35cf5f0f-d5bc-49ad-9704-e6613e60f0fc | |
| relation.isAuthorOfPublication.latestForDiscovery | 35cf5f0f-d5bc-49ad-9704-e6613e60f0fc |