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The Impact of a Western Diet and Resistance Training in a Rat Model of Mammary Cancer

2025Journal article Open access
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datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorSilva, Jessica
dc.contributor.authorFerreira, Rita
dc.contributor.authorNeuparth, Maria J.
dc.contributor.authorSeixas, Fernanda
dc.contributor.authorGinja, Mário
dc.contributor.authorPires, Maria J.
dc.contributor.authorFaustino-Rocha, Ana I.
dc.contributor.authorDuarte, José Alberto
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2025-04-04T08:57:33Z
dc.date.available2025-04-04T08:57:33Z
dc.date.issued2025
dc.description.abstractThis study aimed to investigate the impact of a Western diet and resistance training on cardiac remodeling in a rat model of chemically induced mammary cancer. Fifty-six female Wistar rats were randomly assigned to one of eight experimental groups, evaluating the impact of Western and standard diets, exercise and sedentarism, and the induction of mammary cancer. Mammary cancer was induced via the intraperitoneal administration of N-methyl-N-nitrosourea (MNU) (50 mg/kg) at seven weeks of age. The resistance training protocol consisted of ladder climbing three times per week for an 18-week period, with a gradual increase in load over time. At the end of the 20-week experimental period, the animals were anesthetized and underwent echocardiography. Subsequently, the animals were euthanized, and organs and visceral adipose tissue (VAT) were collected and analyzed. A histopathological examination was performed on the mammary tumors. The Western diet increased relative VAT and contributed to cardiovascular and tumor-related changes, including an increase in interventricular septum thickness (IVS) and left ventricle posterior wall thickness (LVPW) at end-systole. Exercise reduced fat accumulation, improved cardiac performance, and helped regulate cardiovascular function, as indicated by a higher eccentricity index (EI) in the WD+EX group compared to the WD group. The WD was associated with increased VAT accumulation and initially delayed tumor initiation; however, over time, it contributed to bigger tumor aggressiveness. This diet also delayed tumor initiation but increased LVPW. Exercise, when combined with a WD, accelerated tumorigenesis, malignant transformation and invasiveness, resulted in the higher prevalence of invasive tumors. These findings underscore the complex and potentially compounding effects of diet and exercise on cancer progression.eng
dc.description.sponsorshipThis work was supported by national funds from the FCT—Portuguese Foundation for Science and Technology, under the projects UIDB/04033/2020 (CITAB, https://doi.org/10.54499 /UIDB/04033/2020), LA/P/0126/2020 (INOV4AGRO, https://doi.org/10.54499/LA/P/0126/2 020), UIDB/00772/2020 (CECAV, https://doi.org/10.54499/UIDB/00772/2020), LA/P/0059/2020 (AL4AnimalS, https://doi.org/10.54499/LA/P/0059/2020), UIDB/00690/2020 (CIMO; https://doi. org/10.54499/UIDB/00690/2020), and UIDP/00690/2020 (CIMO; https://doi.org/10.54499/UIDP/ 00690/2020), and the doctoral grants awarded to J.S. (2020.07999.BD; https://doi.org/10.54499/2020. 07999.BD) and T.A. (2023.01329.BD; https://doi.org/10.54499/2023.01329.BD).
dc.identifier.citationSilva, Jessica; Araújo Azevedo, Tiago; Ferreira, Rita; Neuparth, Maria J.; Seixas, Fernanda; Ginja, Mário; Pires, Maria J.; Faustino-Rocha, Ana I.; Duarte, José Alberto; Oliveira, Paula A. (2025). The Impact of a Western Diet and Resistance Training in a Rat Model of Mammary Cancer. Vigiliae Christianae: A Review of Early Christian Life and Language. ISSN 2075-1729. 15:2, p. 1-14
dc.identifier.doi10.3390/life15020250
dc.identifier.issn2075-1729
dc.identifier.urihttp://hdl.handle.net/10198/34381
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationInstitute for innovation, capacity building and sustainability of agri-food production
dc.relationVeterinary and Animal Science Research Centre
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relation.ispartofLife
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBreast cancer
dc.subjectExercise training
dc.subjectMurine model
dc.subjectObesity
dc.titleThe Impact of a Western Diet and Resistance Training in a Rat Model of Mammary Cancereng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleInstitute for innovation, capacity building and sustainability of agri-food production
oaire.awardTitleVeterinary and Animal Science Research Centre
oaire.awardTitleAssociate Laboratory for Animal and Veterinary Sciences
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0126%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00772%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0059%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.citation.endPage14
oaire.citation.issue2
oaire.citation.startPage1
oaire.citation.titleVigiliae Christianae: A Review of Early Christian Life and Language
oaire.citation.volume15
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
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