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Characterization of in vitro antioxidant, antitumor and anti-inflammatory properties of plant species from Rosaceae family

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dc.contributor.authorGarcia-Oliveira, Paula
dc.contributor.authorBarral Martínez, Marta
dc.contributor.authorJarboui, Amira
dc.contributor.authorOludemi, Taofiq
dc.contributor.authorGarcía-Pérez, Pascual
dc.contributor.authorPinela, José
dc.contributor.authorMandim, Filipa
dc.contributor.authorSimal-Gandara, Jesus
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorPrieto Lage, Miguel A.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2022-01-20T15:49:59Z
dc.date.available2022-01-20T15:49:59Z
dc.date.issued2021
dc.description.abstractSince ancient times, humans have employed different plant species to prepare traditional remedies and treat diseases, due to the health-promoting effects associated with these plants. Among them, several species belonging to the Rosaceae family, namely Agrimonia eupatoria L., Filipendula ulmaria (L.) Maxim. and Rosa canina L., which have been used in different preparations, like infusions, decoctions or tinctures, to treat diverse illnesses and diseases [1]. Nowadays, the search for natural derived ingredients has prompted the study of these traditional plants. The present work aimed to evaluate the biological properties of the above-mentioned Rosaceae species, in order to promote their applications in different sectors. Antioxidant activity was evaluated by different in vitro assays: 2,2-diphenylpycrilhydrazyl (DPPH) radical scavenging assay, thiobarbituric acid reactive substances (TBARS) assay for inhibition of lipid peroxidation, OxHLIA assay for inhibition of oxidative hemolysis, and reducing power determination. Antitumor activity was tested against four tumor cell lines: MCF-7, CaCo, AGS and NCI-H460. Finally, anti-inflammatory activity was assessed by the inhibition of inflammation on lipopolysaccharide-induced RAW264.7 murine macrophages. Considering the results, all plant extracts showed antioxidant effects in the tested assays, especially F. ulmaria. All tested extracts also displayed relevant antitumor effects against the four tested tumor cell lines, mostly F. ulmaria, which exhibited the lowest growth inhibition 50 values (GI50) ranging from 34 to 86 μg/mL of extract, presenting a noteworthy cytotoxic effect. Finally, R. canina showed significant anti-inflammatory effects, with effective concentration 50 values (EC50) of 20 μg/mL of extract. Therefore, the studied plants may be considered as promising natural sources of bioactive compounds with multifunctional biological properties for the development of several biobased applications.pt_PT
dc.description.sponsorshipThe research leading to these results was supported by MICINN supporting the Ramón y Cajal grant for M.A. Prieto (RYC-2017-22891) and the Juan de la Cierva Formación grant for T. Oludemi (FJC2019-042549-I), by Xunta de Galicia for supporting the program EXCELENCIA-ED431F 2020/12, the pre-doctoral grant of P. Garcia-Oliveira (ED481A-2019/295) and the program Grupos de Referencia Competitiva (GRUPO AA1-GRC 2018) that supports the work of M. Barral-Martinez. Authors are grateful to Ibero-American Program on Science and Technology (CYTED—AQUA-CIBUS, P317RT0003), to the Bio Based Industries Joint Undertaking (JU) under grant agreement No 888003 UP4HEALTH Project (H2020-BBI-JTI-2019) that supports the work of P. Garcia-Perez. The JU receives support from the European Union‘s Horizon 2020 research and innovation program and the Bio Based Industries Consortium. The project SYSTEMIC Knowledge hub on Nutrition and Food Security, has received funding from national research funding parties in Belgium (FWO), France (INRA), Germany (BLE), Italy (MIPAAF), Latvia (IZM), Norway (RCN), Portugal (FCT), and Spain (AEI) in a joint action of JPI HDHL, JPI-OCEANS and FACCE-JPI launched in 2019 under the ERA-NET ERA-HDHL (n° 696295). Authors are also grateful to Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to the CIMO (UIDB/00690/2020).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGarcia-Oliveira, Paula; Barral-Martinez, Marta; Jarboui, Amira; Oludemi, Taofiq; Garcia-Perez, Pascual; Pinela, José; Mandim, Filipa; Simal-Gandara, Jesus; Ferreira, Isabel C.F.R.; Prieto Lage, Miguel A.; Barros, Lillian (2021). Characterization of in vitro antioxidant, antitumor and anti-inflammatory properties of plant species from Rosaceae family. In 5th International Symposium on Phytochemicals in Medicine and Food. Nanchang, Chinapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/24805
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationSustainable and cost-effective production process for the upcycling of olive, grape and nut by-products into 4 natural and healthy ingredients for nutraceutical and cosmetic applications
dc.relationERA-NET Biomarkers for Nutrition and Health implementing the JPI HDHL objectives
dc.relationMountain Research Center - UIDB/00690/2020
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectRosaceae familypt_PT
dc.subjectTraditional remediespt_PT
dc.titleCharacterization of in vitro antioxidant, antitumor and anti-inflammatory properties of plant species from Rosaceae familypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardNumber888003
oaire.awardNumber696295
oaire.awardNumberUIDB/00690/2020
oaire.awardTitleSustainable and cost-effective production process for the upcycling of olive, grape and nut by-products into 4 natural and healthy ingredients for nutraceutical and cosmetic applications
oaire.awardTitleERA-NET Biomarkers for Nutrition and Health implementing the JPI HDHL objectives
oaire.awardTitleMountain Research Center - UIDB/00690/2020
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/888003/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/696295/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.citation.conferencePlaceNachang University, Chinapt_PT
oaire.citation.title5th International Symposium on Phytochemicals in Medicine and Foodpt_PT
oaire.fundingStreamH2020
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGarcía-Oliveira
person.familyNameOludemi
person.familyNamePinela
person.familyNameMandim
person.familyNameFerreira
person.familyNamePrieto
person.familyNameBarros
person.givenNamePaula
person.givenNameTaofiq
person.givenNameJosé
person.givenNameFilipa
person.givenNameIsabel C.F.R.
person.givenNameMiguel A.
person.givenNameLillian
person.identifier144781
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person.identifier.orcid0000-0003-4058-3709
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person.identifier.orcid0000-0002-9050-5189
person.identifier.ridB-4466-2014
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project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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