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The use of mushroom extracts as boatives ingredientes in the development of cosmeceutical formulations

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dc.contributor.authorTaofiq, Oludemi
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorAlves, Maria José
dc.contributor.authorBarros, Lillian
dc.contributor.authorGonzález-Paramás, Ana María
dc.contributor.authorBarreiro, M.F.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2017-01-13T16:27:49Z
dc.date.available2017-01-13T16:27:49Z
dc.date.issued2016
dc.description.abstractThe cosmetic industry is in a constant search for natural compounds, or extracts, with relevant bioactive properties to act as active ingredients. Among the possibilities, mushrooms can play an important role. They are rich sources of bioactive metabolites, known since long for their nutritional and medicinal properties, but underexploited as cosmeceutical ingredients [1]. In the present work, ethanolic extracts obtained from Agaricus bisporus L., Pleurotus ostreatus (Jacq. ex Fr.) P.Kumm. and Lentinula edodes (Berk.) Pegler, purchased in a local supermarket in the Northeast of Portugal, were analysed for their anti-inflammatory activity by quantification of NO production in RAW 264.7 macrophages cells, tyrosinase inhibition assay using L-DOPA as substrate, antioxidant activity by DPPH radical-scavenging and ferricyanide/Prussian blue reducing power assays, and also for their antibacterial activity by determining the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) using the microdilution method. The extracts were chemically characterised in terms of phenolic acids and ergosterol content by HPLC-PDA and HPLC-UV, respectively. The extract samples were further incorporated in a base cosmetic cream considering the EC50 and MIC values previously determined resulting in a scale of 100 mg of extract per gram of base cream. The final formulation was mixed properly to attain sample homogeneity and then evaluated for the same bioactive purposes. In terms of chemical composition, ergosterol and cinnamic, p-hydroxybenzoic, p-coumaric and protocatechuic acids were found in the characterized mushrooms. The mushroom extracts, as well as the final cosmeceutical formulations, were found to display antioxidant, anti-inflammatory, antibacterial and anti-tyrosinase activities. Furthermore, the final cosmeceutical formulations revealed the presence of 85-100% of the phenolic acids and ergosterol levels detected initially in the mushroom extracts. In conclusion, the results suggest that mushroom extracts can be interesting multifunctional cosmeceutical ingredients for topical application to combat skin aging, inflammation and as preservative and hyperpigmentation correcting ingredients.pt_PT
dc.description.sponsorshipProject UID/AGR/00690/2013 (CIMO) and POCI-01-0145-FEDER-006984 (LSRE-LCM), funded by FEDER, through POCI-COMPETE2020 and FCT and Project NORTE-01-0145-FEDER-000006. A.M. González-Paramás is also thankful to the Spanish MINECO/FEDER for financial support through the project AGL2015-64522-C2-2-R.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTaofiq, Oludemi; Heleno, Sandrina A.; Calhelha, Ricardo C.; Alves, Maria José; Barros, Lillian; Gonzáles-Paramás, Ana; Barreiro, M.F.; Ferreira, Isabel C.F.R. (2016). The use of mushroom extracts as boatives ingredientes in the development of cosmeceutical formulations. IN XXII Luso Galego de Química. BRAGANÇA. ISBN 978-989-8124-17-3pt_PT
dc.identifier.isbn978-989-8124-17-3
dc.identifier.urihttp://hdl.handle.net/10198/13776
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleThe use of mushroom extracts as boatives ingredientes in the development of cosmeceutical formulationspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.citation.conferencePlaceBragançapt_PT
oaire.citation.titleXXII Luso Galego de Químicapt_PT
oaire.fundingStream5876
person.familyNameHeleno
person.familyNameCalhelha
person.familyNameAlves
person.familyNameBarros
person.familyNameBarreiro
person.familyNameFerreira
person.givenNameSandrina A.
person.givenNameRicardo C.
person.givenNameMaria José
person.givenNameLillian
person.givenNameFilomena
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id8B18-3095-6FC9
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-idD618-B3A9-D312
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id3418-47D5-5746
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6844-333X
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridL-5951-2014
person.identifier.ridJ-2172-2014
person.identifier.ridM-6624-2016
person.identifier.ridJ-3600-2013
person.identifier.ridL-9802-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id30067731800
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id57188719717
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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