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Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocylces

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dc.contributor.authorAlbuquerque, Hélio
dc.contributor.authorSantos, Clementina M.M.
dc.contributor.authorCavaleiro, José
dc.contributor.authorSilva, Artur
dc.date.accessioned2015-02-23T15:29:12Z
dc.date.available2015-02-23T15:29:12Z
dc.date.issued2014
dc.description.abstractChalcones belong to the flavonoid family which constitutes one of the major classes of naturally occurring oxygen heterocyclic compounds. The alpha,beta-unsaturated carbonyl system of chalcones possesses two electrophilic reactive centers allowing them to participate in addition reactions via attack to the carbonyl group (1,2-addition) or involving the beta-carbon (1,4-conjugate addition), leading to the synthesis of promising bioactive heterocyclic compounds. The purpose of this review is to present a systematic survey of the most recent literature that uses chalcones in the synthesis of biologically active 5- and 6-membered nitrogen heterocycles such as pyrroles, indoles, isoxazoles, imidazoles, pyrazoles, indazoles, triazoles, tetrazoles, pyridines and pyrimidines. Efficiency, easy-to-handle and cheap reagents, alternative heating conditions and greener protocols will be highlighted. In this review we will cover the literature since the beginning of the 21st century in more than 400 publications.por
dc.description.sponsorshipPEst-C/QUI/UI0062/2013 FCOMP-01-0124-FEDER-037296por
dc.identifier.citationAlbuquerque, Hélio; Santos, Clementina M.M.; Cavaleiro, José A.S.; Silva, Artur M.S. (2014). Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocylces. Current Organic Chemistry. ISSN 1385-2728. 18:21, p. 2750-2775por
dc.identifier.doi10.2174/1385272819666141013224253
dc.identifier.issn1385-2728
dc.identifier.urihttp://hdl.handle.net/10198/11671
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherBentham Sciencepor
dc.subjectChalconespor
dc.subjectCycloaddition reactionspor
dc.subjectMichael additionpor
dc.subjectNitrogen heterocyclic compoundspor
dc.subjectReactivitypor
dc.subjectSynthetic methodspor
dc.titleChalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocylcespor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2775por
oaire.citation.startPage2750por
oaire.citation.titleCurrent Organic Chemistrypor
oaire.citation.volume18por
person.familyNameSantos
person.givenNameClementina M.M.
person.identifier.ciencia-id9018-DB9C-C590
person.identifier.orcid0000-0003-4380-7990
person.identifier.scopus-author-id7201458663
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication64f662b6-775d-4ea0-bfd7-f527af0ac1a0
relation.isAuthorOfPublication.latestForDiscovery64f662b6-775d-4ea0-bfd7-f527af0ac1a0

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