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Phytotherapy: A Systematic Review for the Treatment of Hypertension

2025Journal article Open access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosCiências Médicas::Medicina Clínica
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorLachovicz, Rebeca
dc.contributor.authorFerro-Lebres, Vera
dc.contributor.authorAlmeida-de-Souza, Juliana
dc.date.accessioned2025-04-30T13:56:12Z
dc.date.available2025-04-30T13:56:12Z
dc.date.issued2025
dc.description.abstractIntroduction: Approximately 10 million annual deaths may be associated with hypertension. Adverse effects and non-response to pharmacological treatment limit therapy to a significant proportion of patients; hence, treatment alternatives seem necessary. Our objective was to review data about the impact of herbal medicine on reducing blood pressure (BP) in prehypertensive and hypertensive patients. Methods: A systematic review was conducted (PRISMA guidelines), using PUBMED, SCOPUS, and WEB OF SCIENCE databases, without time restriction. The inclusion criteria were randomised controlled trials and quasiexperimental studies in humans focusing antihypertensive effect of phytotherapeutics: Allium sativum, Apium graveolens, Nigella sativa, Panax ginseng, and Hibiscus sabdariffa on BP in adults with prehypertension or hypertension. The exclusion criteria were the usage of combined medicinal plants. Data about systolic and diastolic BP differences before and after phytotherapy were extracted manually and summarised. The risk of bias was assessed using the JBI tool. Results: Forty-five studies were selected (15 A sativum, 4 A graveolens, 4 N sativa, 9 P ginseng, and 13 H sabdariffa). Antihypertensive effect was observed for A sativum systolic and diastolic BP (−18.1/−9 mmHg), A graveolens (−37.9/−15.4 mmHg), N sativa (−11.8/−8.8 mmHg), P ginseng (−17.4/−7.1 mmHg), and H sabdariffa (−61.4/−66.2 mmHg). Discussion/Conclusions: Herbal medicines can reduce high BP levels in prehypertension and hypertension, when used alone or together with lifestyle changes or antihypertensive drugs. Results interpretation is crucial, given the studies quality variation and the discrepancies. More consistent clinical studies in humans are needed to accurately determine efficacy and safety in the treatment of hypertension. eng
dc.description.sponsorshipThe authors are grateful to the national funds through FCT/MCTES (PIDDAC): CIMO, UIDB/00690/2020 (DOI: 10.54499/UIDB/00690/2020) and UIDP/00690/2020 (DOI: 10.54499/UIDP/00690/2020); and SusTEC, LA/P/0007/2020 (DOI: 10.54499/LA/P/0007/2020). The conduct of the research and/or the preparation of the article and the source(s) of funding did not have such involvement. This article is part of Rebeca Lachovicz bachelor's thesis, developed as part of the requirements for obtaining a bachelor's degree. Rebeca Lachovicz was supported by a research initiation grant from the Polytechnic Institute of Bragança
dc.identifier.doi10.1016/j.hermed.2024.100985
dc.identifier.issn2210-8033
dc.identifier.urihttp://hdl.handle.net/10198/34448
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relation.ispartofJournal of Herbal Medicine
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPhytotherapy
dc.subjectHerbal medicine
dc.subjectBlood pressure
dc.subjectPrehypertension
dc.subjectWhite Coat Hypertension
dc.titlePhytotherapy: A Systematic Review for the Treatment of Hypertensioneng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.citation.endPage25
oaire.citation.startPage1
oaire.citation.titleJournal of Herbal Medicine
oaire.citation.volume50
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLachovicz
person.familyNameFerro-Lebres
person.familyNameAlmeida-de-Souza
person.givenNameRebeca
person.givenNameVera
person.givenNameJuliana
person.identifier.ciencia-id3F19-7B8E-1D87
person.identifier.ciencia-idA913-E58F-DACE
person.identifier.ciencia-idFA14-073E-C116
person.identifier.orcid0000-0003-3691-9791
person.identifier.orcid0000-0002-3782-9264
person.identifier.orcid0000-0002-2578-3684
person.identifier.scopus-author-id57194551953
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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