Publication
Synthesis of diarylamines in the benzo[b]thiophene series by palladium-catalyzed amination and structure-activity relationship as antibacterial agents
| dc.contributor.author | Queiroz, Maria João R.P. | |
| dc.contributor.author | Ferreira, Isabel C.F.R. | |
| dc.contributor.author | Barbosa, Sandra | |
| dc.contributor.author | Calhelha, Ricardo C. | |
| dc.contributor.author | Estevinho, Leticia M. | |
| dc.date.accessioned | 2011-03-23T11:55:44Z | |
| dc.date.available | 2011-03-23T11:55:44Z | |
| dc.date.issued | 2004 | |
| dc.description.abstract | The palladium-catalyzed amination of arylhalides has become an important method for the synthesis of arylamines found in pharmaceuticals. Using this methodology we were able to synthesize several diarylamines in the benzo[b]thiophene series.Here we report the synthesis 01 differently substituted diarylamines derivatives 01 6-bromo or 6-amino- 2,3,5-trimethylbenzo[b]thiophene in good to high yields (50-90%) (Scheme), The amino precursor was prepared from the bromo compound using also a C-N palladium-catalyzed cross-coupling with benzophenone imine, followed by acidic hydrolysis in a 60% overall yield. | por |
| dc.identifier.citation | Queiroz, Maria-João R.P.; Ferreira, Isabel C.F.R.; Barbosa, Sandra; Calhelha, Ricardo; Estevinho, Letícia (2004). Synthesis of diarylamines in the benzo[b]thiophene series by palladium-catalyzed amination and structure-activity relationship as antibacterial agents. In International Symposium on Advances in Synthetic, Combinatorial and Medicinal Chemistry. Moscovo | por |
| dc.identifier.uri | http://hdl.handle.net/10198/3728 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.title | Synthesis of diarylamines in the benzo[b]thiophene series by palladium-catalyzed amination and structure-activity relationship as antibacterial agents | por |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Moscovo, Rússia | por |
| oaire.citation.title | International Symposium on Advances in Synthetic, Combinatorial and Medicinal Chemistry | por |
| person.familyName | Ferreira | |
| person.familyName | Calhelha | |
| person.familyName | Estevinho | |
| person.givenName | Isabel C.F.R. | |
| person.givenName | Ricardo C. | |
| person.givenName | Letícia M. | |
| person.identifier | 144781 | |
| person.identifier.ciencia-id | 9418-CF95-9919 | |
| person.identifier.ciencia-id | F313-E3CE-554E | |
| person.identifier.ciencia-id | BA14-09D6-A406 | |
| person.identifier.orcid | 0000-0003-4910-4882 | |
| person.identifier.orcid | 0000-0002-6801-4578 | |
| person.identifier.orcid | 0000-0002-9249-1948 | |
| person.identifier.rid | E-8500-2013 | |
| person.identifier.rid | J-2172-2014 | |
| person.identifier.scopus-author-id | 36868826600 | |
| person.identifier.scopus-author-id | 6507978333 | |
| person.identifier.scopus-author-id | 6506577664 | |
| rcaap.rights | openAccess | por |
| rcaap.type | conferenceObject | por |
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