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Bio-guided fractionation of extracts of Geranium robertianum L.: relationship between phenolic profile and biological activity

2017Journal article Open access
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dc.contributor.authorGraça, Vânia C.
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorSantos, Paulo F.
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-01-29T10:39:37Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-01-29T10:39:37Z
dc.date.issued2017
dc.description.abstractGeranium robertianum L. is used in folk medicine and herbalism practice for the treatment of a variety of ailments. Recently, we studied the bioactivity of several aqueous and organic extracts of this plant. In this work, the more active extracts were fractionated and the fractions evaluated for their antioxidant activity and cytotoxicity against several human tumor cell lines and non-tumor porcine liver primary cells. Some of the fractions from the acetone extract consistently displayed low EC 50 and GI 50 values and presented the higher contents of total phenolic compounds in comparison to other fractions. The phenolic compounds profile of the fractions was determined. The bio-guided fractionation of the extracts resulted in several fractions with improved bioactivity relative to the corresponding extracts. Their lower compositional complexity allowed the identification of more than two dozen compounds, to the best of our knowledge, so far not reported in G. robertianum.pt_PT
dc.description.sponsorshipThis work was supported by European Investment Funds by FEDER/COMPETE/POCI- Operational Competitiveness and Internationalization Programme, under Project POCI-01-0145-FEDER-006958 and National Funds by FCT − Portuguese Foundation for Science and Technology under the projects UID/AGR/04033, UID/AGR/00690/2013 (CIMO) and UID/QUI/00616/2013 (CQ-VR). V.C. Graça, M.I. Dias and L. Barros thank FCT for SFRH/BD/52542/2014, SFRH/BD/84485/2012, and SFRH/BPD/107855/2015 grants, respectively.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGraça, V.C.; Barros, Lillian; Calhelha, Ricardo C.; Dias, Maria Inês; Ferreira, Isabel C.F.R.; Santos, P.F. (2017). Bio-guided fractionation of extracts of Geranium robertianum L.: Relationship between phenolic profile and biological activity. Industrial Crops & Products. ISSN 0926-6690. 108, p. 543-552
dc.identifier.doi10.1016/j.indcrop.2017.07.016pt_PT
dc.identifier.issn09266690
dc.identifier.urihttp://hdl.handle.net/10198/15069
dc.language.isoeng
dc.peerreviewedyespt_PT
dc.relationMountain Research Centre
dc.relationEXTRAÇÃO E AVALIAÇÃO DA ATIVIDADE BIOLÓGICA DE EXTRATOS DE PLANTAS MEDICINAIS DA REGIÃO DE TRÁS-OS-MONTES
dc.relationIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
dc.relationProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
dc.subjectGeranium robertianum L.
dc.subjectFractionation
dc.subjectAntioxidant activity
dc.subjectAntiproliferative activity
dc.subjectPhenolic compounds
dc.titleBio-guided fractionation of extracts of Geranium robertianum L.: relationship between phenolic profile and biological activityen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Centre
oaire.awardTitleEXTRAÇÃO E AVALIAÇÃO DA ATIVIDADE BIOLÓGICA DE EXTRATOS DE PLANTAS MEDICINAIS DA REGIÃO DE TRÁS-OS-MONTES
oaire.awardTitleIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
oaire.awardTitleProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F04033%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAGR%2F00690%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00616%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F52542%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F84485%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F107855%2F2015/PT
oaire.fundingStream5876
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream5876
person.familyNameBarros
person.familyNameCalhelha
person.familyNameDias
person.familyNameFerreira
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameMaria Inês
person.givenNameIsabel C.F.R.
person.identifier469085
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person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idF313-E3CE-554E
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person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridM-8242-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticlept_PT
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