Publication
Recent developments in the synthesis of novel xanthone-1,2,3-triazole dyads
| dc.contributor.author | Albuquerque, Hélio | |
| dc.contributor.author | Santos, Clementina M.M. | |
| dc.contributor.author | Silva, Artur | |
| dc.contributor.author | Cavaleiro, José | |
| dc.date.accessioned | 2016-05-30T14:31:59Z | |
| dc.date.available | 2016-05-30T14:31:59Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | The development of multi-target drugs for treating complex multifactorial diseases constitutes an active research ield. This kind of drugs has gained much importance as alternative strategy to combination therapy (“cocktail drugs”).1 A common way to design them brings together two different pharmacophores in one single molecule (so-called dyads). Following this idea and being aware that xanthones2 and 1,2,3-triazoles3 possess important pharmacological properties, we combined these two heterocycles in one molecule to create new dyads with improved therapeutic potential. In this work, new xanthone-1,2,3-triazole dyads were prepared from novel (E)-2-(4-arylbut-1-en-3-yn-1-yl)chromones by two different approaches to evaluate their eficiency and sustainability. Both methodologies involved Diels-Alder reactions to build the xanthone core, which were optimized using microwave irradiation as alternative heating method, and 1,3-dipolar cycloadditions to insert the 1,2,3-triazole moiety (Figure 1).4 All final and intermediate compounds were fully characterized by 1D and 2D NMR techniques. | pt_PT |
| dc.identifier.citation | Albuquerque, Hélio; Santos, Clementina M.M.; Silva, Artur M. S.; Cavaleiro, J. A. S. (2015). Recent developments in the synthesis of novel xanthone-1,2,3-triazole dyads. In 11º Encontro Nacional de Química Orgânica e 4º Encontro de Química Terapêutica. Porto. ISBN 978-989-98541-9-2 | pt_PT |
| dc.identifier.isbn | 978-989-98541-9-2 | |
| dc.identifier.uri | http://hdl.handle.net/10198/12948 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.title | Recent developments in the synthesis of novel xanthone-1,2,3-triazole dyads | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00062%2F2013/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F86277%2F2012/PT | |
| oaire.citation.conferencePlace | Porto | pt_PT |
| oaire.citation.title | 11º Encontro Nacional de Química Orgânica e 4º Encontro de Química Terapêutica | pt_PT |
| oaire.fundingStream | 5876 | |
| oaire.fundingStream | SFRH | |
| person.familyName | Santos | |
| person.givenName | Clementina M.M. | |
| person.identifier.ciencia-id | 9018-DB9C-C590 | |
| person.identifier.orcid | 0000-0003-4380-7990 | |
| person.identifier.scopus-author-id | 7201458663 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
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