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Complete separation of nadolol stereoisomers by fixed-bed and simulated moving bed chromatography
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Resumo(s)
This work deals with the identification of main experimental strategy for the complete separation of nadolol quaternary mixture into its pure four stereoisomers. Different chiral and achiral adsorbents, with different particle size diameters (5, 10 and 20 m) as well as several solvents and solvent mixtures (aqueous and organic) are used. The selected global strategy is based on two main steps. The first step is the achiral separation of nadolol racemates (two pairs of enantiomers) by high pH reversed-phase preparative chromatography using C18 adsorbents. Then, the second step is based on two parallel binary chiral separations using Chiralpak IA adsorbents. It is important to notice that both first and second steps can be accomplished by fixed-bed and simulated moving bed (SMB) technologies. The theoretical and experimental results show that SMB technology presents higher preparati performance when compared to the "equivalent" preparative fixed-bed operation.
Descrição
Palavras-chave
Chromatography Nadolol Stereoisomers
Contexto Educativo
Citação
Arafah, Rami; Ribeiro, António E.; Rodrigues, Alírio E.; Pais, Luís S. (2023). Complete separation of nadolol stereoisomers by fixed-bed and simulated moving bed chromatography. In 14 th International Chemical and Biological Engineering Confererence.Bragança. ISBN 978-972-745-327-6
Editora
Instituto Politécnico de Bragança