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Chemical composition, diuretic, and antityrosinase activity of traditionally used romanian cerasorum stipites

2021Journal article Open access
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dc.contributor.authorBabotă, Mihai
dc.contributor.authorVoştinaru, Oliviu
dc.contributor.authorPăltinean, Ramona
dc.contributor.authorMihali, Cosmin
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorMocan, Andrei
dc.contributor.authorCrişan, Ovidiu
dc.contributor.authorNicula, Cristina
dc.contributor.authorCrişan, Gianina
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-23T11:27:51Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-23T11:27:51Z
dc.date.issued2021
dc.description.abstractCherry stems (CS) represent a by-product intensively used in Eastern European countries as a traditional remedy for urinary tract disorders. Ethnopharmacological evidences sustain the use of CS as aqueous preparations (infusion and decoction), but few data were previously reported about phytochemical profile and pharmacological potential of CS hydroalcoholic extracts. In this regard, we aimed to evaluate the phenolic profile, in vitro antioxidant and tyrosinase inhibitory potential, and in vivo diuretic activity of 70% hydroethanolic cherry stems extract and cherry stems decoction (CSD). LC-DAD-ESI/MSn analysis revealed the presence of flavonoid-type compounds as main constituents for both preparations, especially flavanones (naringenin glycosides). Antioxidant activity evaluated through DPPH, ABTS, and FRAP methods was superior for cherry stems extract, probably due to the presence of phenolic-derived compounds in higher amounts than CSD. On the other hand, tyrosinase inhibitory potential and diuretic effect exerted by CSD were stronger, highlighting that other types of hydrophilic secondary metabolites are responsible for this bioactivity. Overall, our findings indicate that CS preparations could be used as promising mild diuretic agents and encourage further investigations regarding the correlation between their chemical composition and bioactive potential.en_EN
dc.description.sponsorshipThis work was supported by a Grant of the Romanian Ministry of Education and Research, CCCDI—UEFISCDI, project number PN-III-P2-2.1-PED-2019-5360, within PNCDI III.” The authors MID, LB, and ICFRF are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020) and FCT/MCTES (PIDDAC); national funding by F.C.T. and P.I., through the institutional scientific employment program-contract for MID and LB contracts. To FEDER-Interreg Es-paña- Portugal programme for financial support through the project TRANSCoLAB 0612_TRANS_CO_LAB_2_P.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationBabotă, Mihai; Voştinaru, Oliviu; Păltinean, Ramona; Mihali, Cosmin; Dias, Maria Inês; Barros, Lillian; Ferreira, Isabel C.F.R.; Mocan, Andrei; Crişan, Ovidiu; Nicula, Cristina; Crişan, Gianina (2021). Chemical Composition, Diuretic, and Antityrosinase Activity of Traditionally Used Romanian Cerasorum stipites. Frontiers in Pharmacology. ISSN 1663-9812. 12, p. 1-11en_EN
dc.identifier.doi10.3389/fphar.2021.647947en_EN
dc.identifier.urihttp://hdl.handle.net/10198/24342
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.subjectby-productsen_EN
dc.subjectCerasus sp.en_EN
dc.subjectcherry stemsen_EN
dc.subjectdiuretic activityen_EN
dc.subjectpolyphenolsen_EN
dc.titleChemical composition, diuretic, and antityrosinase activity of traditionally used romanian cerasorum stipitesen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameDias
person.familyNameBarros
person.familyNameFerreira
person.givenNameMaria Inês
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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