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Evaluation of growth inhibitory activity of Crataegus monogyna Jacq. flower bud extracts against human tumor cell lines

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dc.contributor.authorBarreira, João C.M.
dc.contributor.authorAbreu, Rui M.V.
dc.contributor.authorRodrigues, Sandra
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2013-09-09T13:27:30Z
dc.date.available2013-09-09T13:27:30Z
dc.date.issued2013
dc.description.abstractThe vast structural diversity of natural compounds found in plants provides unique opportunities for discovering new drugs with possible beneficial effects on human health, including regulation of proliferation and cell death pathways leading to cancer [1]. Crataegus monogyna Jacq. has been studied by our research group to confirm its different alleged health benefits [2-4]. Herein, the antiproliferative activity of phenolic extracts from C. monogyna flower buds was evaluated on four different human tumor cell lines: HeLa, cervical carcinoma; HepG2, hepatocellular carcinoma; MCF-7, breast adenocarcinoma; NCI-H460, non-small cell lung cancer. The antiproliferative activity was measured by calculating Gl50 values (50% of cell growth inhibition) for each cell line, according to the procedure adopted by the National Cancer Institute for in vitro anticancer drug screening, which uses sulforhodamine B assay to assess cell groW1h inhibition [5]. The obtained antiproliferative activity was very similar among the assayed cell lines: HeLa, Gl50 = 63.55±3.56 μg/ml; HepG2, Gl50 = 88.45±8.11 μg/ml; MCF7, Gl50 = 66.96±0.01 μg/ml ; NCI -H460, Gl50 = 67.61±4.29 μg/ml. The lower activity against HepG2 cells might be related with the type of proliferation of this cell line, the only one with a monolayer growth type among the assayed lines . The activity demonstrated by the phenolic extract of C. monogyna might be explained by their high amounts in flavonoids, which are known for modulating a variety of biological events associated with cancer progression and development, such as cell proliferation, apoptosis, cell differentiation and neovascularization [3]. Accordingly, C. monogyna may be considered as a source of important phytochemicals with bioactive properties to be explored for pharmaceutical applications.por
dc.identifier.citationBarreira, João C.M.; Abreu, Rui M.V.; Rodrigues, Sandra; Carvalho, Ana Maria; Ferreira, Isabel C.F.R. (2013). Evaluation of growth inhibitory activity of Crataegus monogyna Jacq. flower bud extracts against human tumor cell lines. In 1st Symposium on Medicinal Chemistry. Bragapor
dc.identifier.urihttp://hdl.handle.net/10198/8675
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationStrategic Project - UI 690 - 2011-2012
dc.titleEvaluation of growth inhibitory activity of Crataegus monogyna Jacq. flower bud extracts against human tumor cell linespor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.conferencePlaceBraga, Portugalpor
oaire.citation.title1st Symposium on Medicinal Chemistry of University of Minho. 17 de Maio de 2013por
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameBarreira
person.familyNameAbreu
person.familyNameRodrigues
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameJoão C.M.
person.givenNameRui M.V.
person.givenNameSandra
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifierID G-7399-2011
person.identifier144781
person.identifier.ciencia-id0F19-0DE2-12A2
person.identifier.ciencia-id651F-D964-32E1
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person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0002-7745-8015
person.identifier.orcid0000-0003-3301-1729
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridD-8269-2013
person.identifier.ridC-6486-2008
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54895546900
person.identifier.scopus-author-id7003290613
person.identifier.scopus-author-id14048942500
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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